Results 101 to 110 of about 8,709,387 (250)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Rab11-FIP3 is a cell cycle-regulated phosphoprotein [PDF]

, 2012
<b>BACKGROUND:</b> Rab11 and its effector molecule, Rab11-FIP3 (FIP3), associate with recycling endosomes and traffic into the furrow and midbody of cells during cytokinesis.
Xinzi Yu, Simon, G, Glenn Simon, Prekeris, R., Simon, G., Matheson Johanne, Miller, MC, Collins, L.L., Miller, M Clare, Otani Tetsuhisa, Rytis Prekeris, M Clare Miller, Hayashi, S, Yu Xinzi, Prekeris Rytis, Yu, X, Otani, Tetsuhisa, Gould, Gwyn W, Matheson, J., Prekeris, R, Shigeo Hayashi, Gould, GW, Louise L Collins, Miller, M.C., Wu, C., Collins, LL, Christine Wu, Hayashi, Shigeo, Collins Louise L, Hayashi Shigeo, Simon, Glenn, Yu, Xinzi, Miller M Clare, Simon Glenn, Otani, T, Matheson, Johanne, Yu, X., Gould, G.W., Wu, Christine, Collins, Louise L, Gwyn W Gould, Tetsuhisa Otani, Wu, C, Johanne Matheson, Otani, T., Hayashi, S., Prekeris, Rytis, Wu Christine, Matheson, J, Gould Gwyn W   +49 more
core   +1 more source

TAF15 mediates ROP16-induced apoptosis and cell cycle arrest in lung cancer

Parasites & Vectors
Objective This study aimed to investigate the effects of the interaction between ROP16 and TAF15 on apoptosis and cell cycle regulation in A549 lung adenocarcinoma cells.
Guangqi Li, Mei Tian, Yuning Zhou, Shaohan Ma, Shanni Ma, Qirui Ge, Zhijun Zhao   +6 more
doaj   +1 more source

A Method for Analyzing the Ubiquitination and Degradation of Aurora-A

Biological Procedures Online, 2002
The cell cycle machinery consists of regulatory proteins that control the progression through the cell cycle ensuring that DNA replication alternates with DNA segregation in mitosis to maintain cell integrity.
Klotzbucher Andrea, Pascreau Gaetan, Prigent Claude, Arlot-Bonnemains Yannick   +3 more
doaj   +1 more source

Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images. [PDF]

PLoS Comput Biol, 2022
Pécot T, Cuitiño MC, Johnson RH, Timmers C, Leone G.   +4 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Yeast UBL-UBA proteins have partially redundant functions in cell cycle control

Cell Division, 2006
Background Proteins containing ubiquitin-like (UBL) and ubiquitin associated (UBA) domains have been suggested to shuttle ubiquitinated substrates to the proteasome for degradation. There are three UBL-UBA containing proteins in budding yeast: Ddi1, Dsk2
Clarke Duncan J, Walters Kylie J, Kang Yang, Díaz-Martínez Laura A   +3 more
doaj   +1 more source

Curcumin Sensitises Cancerous Kidney Cells to TRAIL Induced Apoptosis via Let-7C Mediated Deregulation of Cell Cycle Proteins and Cellular Metabolism. [PDF]

Int J Mol Sci, 2022
Obaidi I, Blanco Fernández A, McMorrow T.   +2 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis [PDF]

, 2006
Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis ...
Blaydes, J.P., J. P. Blaydes, Bergman, L.M., L. M. Bergman   +3 more
core   +1 more source