Results 101 to 110 of about 1,866,493 (305)

Relationship between the Release of Interleukin 12 and the Expression of PCNA, Cyclin A2, and CDK2 in Lung Cancer Cells

Journal of Oncological Sciences
Objective: Mesenchymal stem cell (MSC)-based IL-12 release therapy may be less toxic than direct administration of IL-2. We investigated the release of interleukin (IL)-12 in MSCs and A549 cocultures and identified the time points at which IL-12 is ...
Meliha Burcu IRMAK YAZICIOĞLU, Seval TURNA   +1 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria [PDF]

, 2016
In all living organisms, the phosphorylation of proteins modulates various aspects of their functionalities. In eukaryotes, protein phosphorylation plays a key role in cell signaling, gene expression, and differentiation.
Derouiche, Abderahmane, Garcia-Garcia, Transito, Mijakovic, Ivan, Noirot-Gros, Marie-Francoise, Poncet, Sandrine, Shi, Lei   +5 more
core   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]

, 2019
Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister, Beadle, Belin, Bennett, Britton, Buxboim, Charlotte R. Pfeifer, Cho, Cornelius, Cumming, Dazhen Liu, Denais, Dennis E. Discher, Dong, Duheron, Emily J. Chen, Frigault, Garay, Giese, Gomes, Grundy, Harada, Harding, Hatch, Houtgraaf, Imlay, Irena L. Ivanovska, Irianto, Irianto, Ivkovic, Jerome Irianto, Kalia Pannell, Khatau, Kryston, Kuangzheng Zhu, Lawrence J. Dooling, Lee, Liu, Liu, Lu, Lucas R. Smith, López-Bigas, Maciejowski, Mahaseth, Mai Wang, Mavrakis, Mello Filho, Michael P. Tobin, Mogilner, Morita, Pajerowski, Pathak, Petrie, Pfeifer, Pfeifer, Raab, Raab, Radisky, Rancati, Rice, Rico, Rizvi, Roger A. Greenberg, Sancar, Skamagki, Strano, Stroka, Surcel, Takaki, Thiam, Thomas, Turgay, Wang, Wolf, Xia, Yan, Yuntao Xia, Zhang   +77 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells

Stem Cell Research, 2014
The shortage of molecular information on cell cycle changes along embryonic stem cell (ESC) differentiation prompts an in silico approach, which may provide a novel way to identify candidate genes or mechanisms acting in coordinating the two programs. We
Angela Re, Christopher T. Workman, Levi Waldron, Alessandro Quattrone, Søren Brunak   +4 more
doaj   +1 more source

DNA repair: Disorders [PDF]

, 2010
No description ...
Bose, Burg, Caldecott, Chu, Digweed, Fernandez-Capetillo, Fousteri, Fousteri, Friedberg, Gudmundsdottir, Hashimoto, Hoeijmakers, Jiricny, Kraemer, Lavin, Lehmann, Lieber, Ma, Masutani, McCulloch, Meindl, Moldovan, Moshous, Nance, Nouspikel, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Rass, Stefanini, Stewart, Stracker, Taylor, Vaz, Wu, Zlatanou   +36 more
core   +1 more source