Results 211 to 220 of about 3,307,555 (359)

RIPK1 autophosphorylation at S161 mediates cell death and inflammation. [PDF]

J Exp Med
Koerner L, Li X, Silnov E, Laurien L, Pasparakis M.   +4 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells. [PDF]

, 1993
Apurva Sarin, David Adams, Pierre A. Henkart   +2 more
openalex   +1 more source

Insights into O-GlcNAcylation and programmed cell death in cancer. [PDF]

Front Cell Dev Biol
Yan X, Ren W, Zhu Z, Li S, Shi R, Sun K, Zhi K, Gao L, Zheng J.   +8 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Gangliosides rescue neuronal cells from death after trophic factor deprivation [PDF]

, 1993
G. Ferrari, Anna Batistatou, LA Greene
openalex   +1 more source

Mitochondria as the central regulator of cell death in bronchopulmonary dysplasia. [PDF]

Front Physiol
Zhang F, Wang L, Zhou Y.
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Cytolysis of nucleated cells by complement: cell death displays multi-hit characteristics.

, 1983
C.L. Koski, L E Ramm, C H Hammer, Manfred M. Mayer, M L Shin   +4 more
openalex   +1 more source

Quantitative analysis of adenine nucleotides during the prelytic phase of cell death mediated by C5b-9. [PDF]

, 1991
John C. Papadimitriou, L E Ramm, Cinthia B. Drachenberg, B F Trump, Minkyu Shin   +4 more
openalex   +1 more source