Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
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Numerical matching between granule and Purkinje cells in lurcher chimeric mice: a hypothesis for the trophic rescue of granule cells from target-related cell death [PDF]
, 1989 Michael W. Vogel +2 more
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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Evidence for soluble factors regulating cell death and cell proliferation in primary cultures of rabbit endometrial cells grown on collagen. [PDF]
, 1986 Maureen P. Lynch +2 more
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
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Cell death during gangliogenesis in the leech: competition leading to the death of PMS neurons has both random and nonrandom components [PDF]
, 1987 ER Macagno, RR Stewart
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Protective Effects of Insulin in Cardiomyocytes Against Iron-mediated Cell Death
, 2019 When an acute myocardial infarction (MI) occurs, the heart becomes ischemic. Medical treatments such as stents have improved the recovery process after a MI, but there is still a high risk for heart failure.
Matsui, M.D., Ph.D., FAHA, Takashi +1 more
core
Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?
Molecular Oncology, EarlyView.Chen‐xi Li, Zhong‐cheng Gong
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Pathophysiology of ischemic cell death: II. Changes in plasma membrane permeability and cell volume. [PDF]
, 1983 A. Ames, Frances B. Nesbett
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