Results 201 to 210 of about 8,637,589 (310)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Metal-dependent regulated cell death: Molecular architecture and translational frontiers. [PDF]

Imeta
Hu H, Chen Z, Li Y, Peng J, Cao J, Zhou H, Wang M, Du Y, Wu H, Zhao H, Huang S, Yu D, Liu M, Shevchenko OV, Matveeva NY, Yang Y, Huang K, Lv D, Min J, Chen L, Wang F.   +20 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The Central Role of Neuronal Cell Death in Alzheimer's Disease Pathobiology. [PDF]

Biomedicines
Kwak S, Kim JK, Lee YU, Baek HS, Kwon YJ, Park MN, Hong JH, Lee SB, Kim HW, Kim S.   +9 more
europepmc   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress. [PDF]

Nat Commun
Casterton R, Martinez-Cotrina A, Barnard J, Wycherley E, Hu Y, Anderson R, Janel S, Byun J, Houghton O, Solomon DA, Alcalde J, Lafont F, Ruepp MD, Hirth F, Tummers B, Cho YY, De Nicola G, Mizielinska S, Fanto M.   +18 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Programmed cell death: a promising management for Alzheimer's disease. [PDF]

Apoptosis
Yang Q, Ren X, Jia R, Zheng L, Ou R, Xu Y, Luo Y, Yang G, Wang X.   +8 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Caspases and programmed cell death in sepsis: mechanisms, pathophysiology, and therapeutic targets. [PDF]

Front Immunol
He H, Xie X, Zhou L, Lin Y, Liu A, Guo P, Zhu Y, Tang Y, Han Z, Wang Y, Chen H.   +10 more
europepmc   +1 more source