Results 221 to 230 of about 3,407,912 (356)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Pharmacological analysis on the rise of the nuclear calcium by glutamate and its role in neuronal cell death

, 2000
Kohtaro Kato, Jie Li, Jun-iti Ikeda, Ikuo Morita, Sei‐itsu Murota   +4 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Redefining cell death: ferroptosis as a game-changer in ophthalmology. [PDF]

Front Immunol
Wei Y, Lin Y, Li Y, Liu J, Yang Y, Chen H, Han Z, Wang K, Qian T, Ju Y, Zheng W.   +10 more
europepmc   +1 more source

An oncolytic adenovirus 11p vector expressing adenovirus death protein in the E1 region showed significant apoptosis and tumour-killing ability in metastatic prostate cells [PDF]

, 2019
Haidong Wu, Ya-Fang Mei
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? [PDF]

Biomedicines
Mónaco A, Chilibroste S, Plata MC, Chabalgoity JA, Moreno M.   +4 more
europepmc   +1 more source

Cell Death and Defence Gene Responses in Plant-Fungal Interactions [PDF]

, 2008
Mattias Persson
openalex  

REGULATION OF X CHROMOSOME-LINKED INHIBITOR OF APOPTOSIS PROTEIN (XIAP) IN KAINIC ACID INDUCED NEURONAL CELL DEATH IN THE RAT HIPPOCAMPUS

, 2001
Laura Korhonen, Natale Belluardo, Dan Lindholm   +2 more
openalex   +1 more source