Results 301 to 310 of about 3,307,555 (359)

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source

Cell Death Modalities in Therapy of Melanoma. [PDF]

Int J Mol Sci
Wang M, Zhao JH, Tang MX, Li M, Zhao H, Li ZY, Liu AD.   +6 more
europepmc   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Correction to "Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death". [PDF]

EJHaem
europepmc   +1 more source

Promotion of HIV clearance by sensitization of HIV reservoirs to cell death. [PDF]

Front Immunol
Li M, Sun B, Dong J, Li JR, Minze LJ, Chen M, Cheng C, Wang J.   +7 more
europepmc   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

The Role of c‑Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma. [PDF]

ACS Omega
Sensenbach S, Ngo HG, Ghosh S, Karki P, Angardi V, Orman MA.   +5 more
europepmc   +1 more source

Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death. [PDF]

Oncoimmunology
Alvarez-Valadez K, Pol JG, Kroemer G, Djavaheri-Mergny M.   +3 more
europepmc   +1 more source

Lesser-known non-apoptotic programmed cell death in viral infections. [PDF]

Virus Res
Wu J, Qian X, Bai S, Wu L, Zhao X.
europepmc   +1 more source