Results 171 to 180 of about 6,985,758 (299)

Expression and Role of the RNA-Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function. [PDF]

Eur J Immunol
Carslaw HA, Woolliscroft S, Watson EM, Bell SE, Linterman MA, Turner M, Webb LMC.   +6 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

ZNF512B associates with mitotic spindles, regulates metaphase exit, and is crucial for stem cell differentiation. [PDF]

Nucleic Acids Res
Paasche LW, Daus N, Groos JJ, Diegmüller F, Kreienbaum C, Kobakhidze E, Lan J, Leers J, Wunderlich S, Scheibe M, Butter F, Borchers A, Mackay JP, Wunderlich TM, Hake SB.   +14 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Tumors mimic the niche to inhibit neighboring stem cell differentiation. [PDF]

Elife
Zhang Y, Wang Y, Song J, Yan L, Wang Z, Song D, Wang H, Yang S, Niu L, Sun C, Zhang H, Zhao Y, Zhao S.   +12 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Red blood cell differentiation using canine-induced pluripotent stem cells. [PDF]

Stem Cells Transl Med
Kimura K, Tsukamoto M, Shishida K, Sugisaki H, Katahira J, Tanaka M, Kuwamura M, Kol A, Okada M, Iijima M, Nakanishi M, Sugiura K, Hatoya S.   +12 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface-Condensate Trajectory. [PDF]

Adv Sci (Weinh)
Klingberg T, Wachter I, Pancholi A, Akyel M, Gohar Y, Kumar P, Fernandes AM, Bao Y, Schmidt-Heydt A, Piepers M, Günthel A, Sobucki M, Kämmer E, Eroğlu-Kayıkçı S, Allgeier S, Erhardt S, Zaburdaev V, Ferrai C, Hilbert L.   +18 more
europepmc   +1 more source