Results 221 to 230 of about 1,782,327 (317)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Sustained PRC1.1 activity preserves gene repression independently of PRC2.2 and restrains leukemic cell differentiation. [PDF]

Nucleic Acids Res
Mojallali F, De Meis A, Alkema SG, Atsma TJ, Hogeling SM, Kloosterman R, Ioannou E, Wierenga ATJ, Huls G, Martens JHA, Schuringa JJ, van den Boom V.   +11 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Histone Lactylation Enhances Th17 Cell Differentiation Through DPP4 to Promote Epithelial-Mesenchymal Transition in Asthma. [PDF]

Lung
Zhong X, Luo Y, Su J, Liang Y, Ding K, He X, Xiao B, Hou L, Xue F, Zhou G, Ling F, Gou Y, Ma L.   +12 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Synergistic effects of dexamethasone and vitamins D and K on mesenchymal stem cell differentiation. [PDF]

Biomed Eng Online
Dvorakova J, Kolaja Dobra J, Hauer L, Kocanek Chocholata P, Cedikova M, Nekleionova A, Babuska V.   +6 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Stress vesicles link epidermal mechanotransduction to stem cell differentiation. [PDF]

Nat Commun
Huang S, Kuri P, Zou J, Blanco A, Marshall M, Rice G, Prouty S, Dentchev T, Doepner M, Boerckel JD, Capell BC, Ridky TW, Rompolas P.   +12 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

ZFP148 is a transcriptional repressor of cytolytic effector CD8⁺ T cell differentiation. [PDF]

Nat Immunol
Xiao T, Chen X, Song NJ, Brown RJ, Ma A, Mandula JK, Yousif A, Wang Y, Le MQM, Li J, Gao F, Weaver B, Chen HY, Lay FY, Sundi D, Velegraki M, Weltge P, Merchant JL, Rubinstein MP, Oestreich KJ, Lio CJ, Ghoneim HE, Li X, Theodorescu D, Xin G, Ma Q, Cui W, Li Z.   +27 more
europepmc   +1 more source