Results 111 to 120 of about 12,578,619 (347)

PP 4.15 – 00181 Distinctive cytoskeletal properties are implicated in the resistance of a fraction of productively HIV-infected CD4+ T-cells to killing by cytotoxic T lymphocytes (CTL)

, 2022
Louise Leyre, Alberto Herrera, P. Zumbo, Jared Weiler, Y. Zhang, E. McNeil, Noemi Linden, Doron Betel, Scott R. Manalis, R.B. Jones, Dennis C. Copertino, Sandra Terry   +11 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates [PDF]

, 2000
Vilasini Shetty, Seema Hussaini, L Broady-Robinson, Krishnan Allampallam, Suneel Mundle, Raphael Borok, Eileen Broderick, Lucia Mazzoran, Francesca Zorat, Azra Raza   +9 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other

, 2014
Ritesh Sachdev, AseemK Tiwari, Shalini Goel, Vimarsh Raina, Monisha Sethi   +4 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Protocol for optimized nasal mucosa sample processing to obtain high-quality scRNA-seq and scATAC-seq data

STAR Protocols
Summary: Examining nasal mucosa samples is crucial for nasal cavity disease research and diagnosis. Simultaneously obtaining high-quality data for single-cell transcriptomics (single-cell RNA sequencing [scRNA-seq]) and epigenomics (single-cell assay for
Yaling Huang, Yisha Wu, Shikai Han, Qiaoling Wang, Guomingxiu Cong, Zhongzhen Liu, Shuyan Guan, Xiaojuan Huang, Ying Liu, Jianhua Yin, Jinmei Xue, Chuanyu Liu   +11 more
doaj   +1 more source

Antioxidant effect and inhibitory activities of ethyl acetate fraction from Gardenia jasminoides extract on nitric oxide production and pancreatic cancer cell proliferation [PDF]

, 2018
Min Kyung Park, Hye Ji Yoon, Hwa Jin Lee
openalex   +1 more source

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Nature Cell Biology, 2018
Haiying Zhang, D. Freitas, Han Sang Kim, K. Fabijanic, Zhong Li, Hai-yan Chen, M. T. Mark, H. Molina, A. Martin, L. Bojmar, Justin Fang, Sham Rampersaud, Ayuko Hoshino, Irina R Matei, C. Kenific, M. Nakajima, A. Mutvei, P. Sansone, Weston Buehring, Huajuan Wang, J. Jiménez, L. Cohen-Gould, N. Paknejad, M. Brendel, K. Manova-Todorova, A. Magalhães, J. Ferreira, H. Osório, André M. N. Silva, Ashish C. Massey, J. Cubillos-Ruiz, G. Galletti, P. Giannakakou, A. Cuervo, J. Blenis, R. Schwartz, M. Brady, H. Peinado, J. Bromberg, H. Matsui, C. Reis, D. Lyden   +41 more
semanticscholar   +1 more source