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FEBS Letters, 2007 Cell–cell fusion is a highly regulated and dramatic cellular event that is required for development and homeostasis. Fusion may also play a role in the development of cancer and in tissue repair by stem cells. While virus–cell fusion and the fusion of intracellular membranes have been the subject of intense investigation during the past decade, cell ...
Elizabeth H Chen +2 more
exaly +5 more sources
Cell fusion in osteoclastogenesis. [PDF]
Biochem Soc TransMultinucleated osteoclasts, generated by fusion of mononucleated precursors, play an essential role in the lifelong remodeling of our bones. Since within the physiological range of osteoclast sizes, their bone-resorbing activity grows with successive fusion events, both initiation of this fusion reaction and its switch off are tightly controlled.
Chernomordik LV, Melikov K.
europepmc +4 more sources
The Zinc Finger Protein Zfp2 Regulates Cell–Cell Fusion and Virulence in Cryptococcus neoformans [PDF]
Journal of FungiCryptococcus neoformans is a fungal pathogen commonly found in the environment. It mainly infects immunocompromised individuals, causing cryptococcal pneumonia and meningitis, which result in hundreds of thousands of deaths each year.
Cheng-Li Fan +3 more
doaj +2 more sources
Separate, separated, and together: the transcriptional program of the Clostridium acetobutylicum-Clostridium ljungdahlii syntrophy leading to interspecies cell fusion [PDF]
mSystemsSyntrophic cocultures (hitherto assumed to be commensalistic) of Clostridium acetobutylicum and Clostridium ljungdahlii, whereby CO2 and H2 produced by the former feed the latter, result in interspecies cell fusion involving large-scale exchange of ...
Noah B. Willis +1 more
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Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity [PDF]
Frontiers in ImmunologyNumerous studies have investigated the molecular mechanisms and signalling pathways underlying cancer metastasis, as there is still no effective treatment for this terminal stage of the disease.
Eduardo López-Collazo +5 more
doaj +2 more sources
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion [PDF]
Journal of Biological Chemistry, 2021 Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a common step, cell-cell fusion. Recent years have brought about considerable progress in identifying some of the proteins involved in these and other cell-fusion processes.
Jarred M. Whitlock +1 more
openaire +2 more sources
Confusion on Cell Fusion [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2021 Cell fusion, whereby two cells merge to create one, has been widely described in development, but the role of cell fusion in tissue regeneration and homeostasis remains an open debate. We propose that the regenerative capacity of the gut can be fully attributed to extensive plasticity of the intestinal epithelium.
Ramadan, Rana, Vermeulen, Louis
openaire +3 more sources
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion
eLife, 2022 TMEM16F, a Ca2+-activated phospholipid scramblase (CaPLSase), is critical for placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated syncytialization, however, how TMEM16F is activated during cell fusion is unclear.
Yang Zhang +8 more
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Viruses, 2023 Human endogenous retrovirus type W (HERV-W) is expressed in various cancers. We previously developed an adenovirus-vectored cancer vaccine targeting HERV-W by encoding an assembled HERV-W group-specific antigen sequence and the HERV-W envelope sequence ...
Isabella Skandorff +7 more
doaj +1 more source
Generating Heterokaryotic Cells via Bacterial Cell-Cell Fusion
Microbiology Spectrum, 2022 Fusion of cells is an important and common biological process that leads to the mixing of cellular contents and the formation of multinuclear cells. Cell fusion occurs when distinct membranes are brought into proximity of one another and merge to become ...
Shraddha Shitut +7 more
doaj +1 more source