WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex [PDF]
Frontiers in Microbiology, 2020 The formation of the fungal mycelial network is facilitated by somatic cell fusion of germinating asexual spores (or germlings). Neurospora crassa germlings in close proximity display chemotropic growth that is dependent upon an intracellular network of ...
A. Pedro Gonçalves +4 more
doaj +4 more sources
Separate, separated, and together: the transcriptional program of the Clostridium acetobutylicum-Clostridium ljungdahlii syntrophy leading to interspecies cell fusion [PDF]
mSystemsSyntrophic cocultures (hitherto assumed to be commensalistic) of Clostridium acetobutylicum and Clostridium ljungdahlii, whereby CO2 and H2 produced by the former feed the latter, result in interspecies cell fusion involving large-scale exchange of ...
Noah B. Willis +1 more
doaj +2 more sources
Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity [PDF]
Frontiers in ImmunologyNumerous studies have investigated the molecular mechanisms and signalling pathways underlying cancer metastasis, as there is still no effective treatment for this terminal stage of the disease.
Eduardo López-Collazo +5 more
doaj +2 more sources
Bone Marrow Myeloid-Lymphatic Progenitors Expand Tumor Lymphatic Vasculature Through Cell Fusion. [PDF]
Cancers (Basel)Athaiya S +5 more
europepmc +3 more sources
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion [PDF]
Journal of Biological Chemistry, 2021 Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a common step, cell-cell fusion. Recent years have brought about considerable progress in identifying some of the proteins involved in these and other cell-fusion processes.
Jarred M. Whitlock +1 more
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Confusion on Cell Fusion [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2021 Cell fusion, whereby two cells merge to create one, has been widely described in development, but the role of cell fusion in tissue regeneration and homeostasis remains an open debate. We propose that the regenerative capacity of the gut can be fully attributed to extensive plasticity of the intestinal epithelium.
Ramadan, Rana, Vermeulen, Louis
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Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion
eLife, 2022 TMEM16F, a Ca2+-activated phospholipid scramblase (CaPLSase), is critical for placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated syncytialization, however, how TMEM16F is activated during cell fusion is unclear.
Yang Zhang +8 more
doaj +1 more source
Viruses, 2023 Human endogenous retrovirus type W (HERV-W) is expressed in various cancers. We previously developed an adenovirus-vectored cancer vaccine targeting HERV-W by encoding an assembled HERV-W group-specific antigen sequence and the HERV-W envelope sequence ...
Isabella Skandorff +7 more
doaj +1 more source
The hallmarks of cell-cell fusion [PDF]
Development, 2017 Cell-cell fusion is essential for fertilization and organ development. Dedicated proteins known as fusogens are responsible for mediating membrane fusion. However, until recently, these proteins either remained unidentified or were poorly understood at the mechanistic level. Here, we review how fusogens surmount multiple energy barriers to mediate cell-
Javier M. Hernández +1 more
openaire +2 more sources
Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment [PDF]
, 2009 Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Henschler, Reinhard +4 more
core +14 more sources