Results 1 to 10 of about 762,610 (162)

A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

eLife, 2020
Cell-cell fusion, which is essential for tissue development and used by some viruses to form pathological syncytia, is typically driven by fusogenic membrane proteins with tall (>10 nm) ectodomains that undergo conformational changes to bring apposing
Ka Man Carmen Chan, Sungmin Son, Eva M Schmid, Daniel A Fletcher   +3 more
doaj   +1 more source

“Keep on rolling”: circulating cells in a botryllid ascidian torpor

Frontiers in Ecology and Evolution, 2023
Hemocytes of the colonial tunicate Botrylloides leachii play important roles throughout the animal’s life span, including transport and storage of nutrients, respiration, regeneration, budding, sexual reproduction, defense responses, and tunic generation.
Yosef Hyams, Yosef Hyams, Julia Panov, Elizaveta Taranenko, Leonid Brodsky, Yuval Rinkevich, Baruch Rinkevich   +6 more
doaj   +1 more source

Neurospora crassa NADPH Oxidase NOX-1 Is Localized in the Vacuolar System and the Plasma Membrane

Frontiers in Microbiology, 2019
The NADPH oxidases (NOX) catalyze the production of superoxide by transferring electrons from NADPH to O2, in a regulated manner. In Neurospora crassa NOX-1 is required for normal growth of hyphae, development of aerial mycelium and asexual spores, and ...
Nallely Cano-Domínguez, Barry Bowman, Leonardo Peraza-Reyes, Jesús Aguirre   +3 more
doaj   +1 more source

Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein

eLife
The bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cells – generated ...
Evgenia Leikina, Jarred M Whitlock, Kamran Melikov, Wendy Zhang, Michael P Bachmann, Leonid Chernomordik   +5 more
doaj   +1 more source

Monoclonal Antibody against Porcine LAG3 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection

Veterinary Sciences
Lymphocyte activation gene 3 (LAG3) is an inhibitory receptor and the interaction between fibrinogen-like protein 1 and LAG3 can inhibit the anti-tumor effect of T cells both in vivo and in vitro, which was regarded as a new immune evasion mechanism ...
Hui Wang, Xu Zheng, Danyang Zheng, Xiaoqian Wang, Zhiqian Zhao, Mi Zhao, Qiang Guo, Yang Mu   +7 more
doaj   +1 more source

Degree of Suppression of Mouse Myoblast Cell Line C2C12 Differentiation Varies According to Chondroitin Sulfate Subtype

Marine Drugs, 2016
Chondroitin sulfate (CS), a type of glycosaminoglycan (GAG), is a factor involved in the suppression of myogenic differentiation. CS comprises two repeating sugars and has different subtypes depending on the position and number of bonded sulfate groups ...
Katsuhiko Warita, Nana Oshima, Naoko Takeda-Okuda, Jun-ichi Tamura, Yoshinao Z. Hosaka   +4 more
doaj   +1 more source

Cell Fusion-Related Proteins and Signaling Pathways, and Their Roles in the Development and Progression of Cancer

Frontiers in Cell and Developmental Biology, 2022
Cell fusion is involved in many physiological and pathological processes, including gamete binding, and cancer development. The basic processes of cell fusion include membrane fusion, cytoplasmic mixing, and nuclear fusion.
Hao Zhang, Hong Ma, Xiaohui Yang, Linlin Fan, Shifeng Tian, Rui Niu, Man Yan, Minying Zheng, Shiwu Zhang   +8 more
doaj   +1 more source

An Attempt at Fusing Primordial Germ Cell with Embryonic Blood Cell in Chickens Using Inactivated Sendai Virus or Electrical Stimulation

The Journal of Poultry Science, 2005
In order to produce nuclear transferred PGCs, fusion of primordial germ cell (PGC) with embryonic blood cell (EBC) was attempted. PGCs and EBCs were isolated from the blood of stages 13-15 embryos.
Mitsuru Naito, Takashi Harumi, Yuko Matsubara, Takashi Kuwana   +3 more
doaj   +1 more source

Unilateral Cleavage Furrows in Multinucleate Cells

Cells, 2020
Multinucleate cells can be produced in Dictyostelium by electric pulse-induced fusion. In these cells, unilateral cleavage furrows are formed at spaces between areas that are controlled by aster microtubules.
Julia Bindl, Eszter Sarolta Molnar, Mary Ecke, Jana Prassler, Annette Müller-Taubenberger, Günther Gerisch   +5 more
doaj   +1 more source

Multiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific activity

Journal of Virology
Fusion-associated small transmembrane (FAST) proteins are viral nonstructural proteins that mediate cell-cell fusion to form multinucleated syncytia. We previously reported that human species B rotavirus NSP1-1 is a FAST protein that induces syncytia in ...
Kylie Sartalamacchia, Vanesa Veletanlic, Julia R. Diller, Kristen M. Ogden   +3 more
doaj   +1 more source