Cell fusion in osteoclastogenesis [PDF]
Multinucleated osteoclasts, generated by fusion of mononucleated precursors, play an essential role in the lifelong remodeling of our bones. Since within the physiological range of osteoclast sizes, their bone-resorbing activity grows with successive fusion events, both initiation of this fusion reaction and its switch off are tightly controlled.
Leonid V. Chernomordik, Kamran Melikov
openaire +4 more sources
Spatiotemporal compartmentalization of NADPH oxidase signaling coordinates cell fusion and predatory behavior in nematode-trapping fungi [PDF]
Reactive oxygen species (ROS) act both as cytotoxic agents and essential signaling molecules. In the nematode-trapping fungus Arthrobotrys flagrans, we investigated how ROS coordinate the development and function of adhesive trapping networks used to ...
Marius Kriegler +3 more
doaj +2 more sources
The Zinc Finger Protein Zfp2 Regulates Cell–Cell Fusion and Virulence in Cryptococcus neoformans [PDF]
Cryptococcus neoformans is a fungal pathogen commonly found in the environment. It mainly infects immunocompromised individuals, causing cryptococcal pneumonia and meningitis, which result in hundreds of thousands of deaths each year.
Cheng-Li Fan +3 more
doaj +2 more sources
Separate, separated, and together: the transcriptional program of the Clostridium acetobutylicum-Clostridium ljungdahlii syntrophy leading to interspecies cell fusion [PDF]
Syntrophic cocultures (hitherto assumed to be commensalistic) of Clostridium acetobutylicum and Clostridium ljungdahlii, whereby CO2 and H2 produced by the former feed the latter, result in interspecies cell fusion involving large-scale exchange of ...
Noah B. Willis +1 more
doaj +2 more sources
Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity [PDF]
Numerous studies have investigated the molecular mechanisms and signalling pathways underlying cancer metastasis, as there is still no effective treatment for this terminal stage of the disease.
Eduardo López-Collazo +5 more
doaj +2 more sources
Role of hypoxia in promoting migration and cell fusion of urine-derived stem cells
Objective To explore the effect of hypoxia on cell migration and fusion of urine-derived stem cells (USCs) in vitro, and observe the changes in cytoskeleton and cell polarity during the process.
ZHANG Nannan, HU Chaoqun, HE Yun
doaj +1 more source
Cell fusions are important to fertilization, placentation, development of skeletal muscle and bone, calcium homeostasis and the immune defense system. Additionally, cell fusions participate in tissue repair and may be important to cancer development and progression.
Larsson, Lars-Inge +2 more
openaire +3 more sources
Core size effects of laser fusion subcritical research reactor for fusion engineering research [PDF]
A multi-purpose high repetition laser facility, the so-called Japan establishment for power-laser community harvest (J-EPoCH) is proposed as a next generation laser facility. J-EPoCH will operate at the maximum rate of 100 Hz.
Kodama, Ryousuke, Iwamoto, Akifumi
core +1 more source
Cell fusion and plasticity [PDF]
Cell plasticity is a central issue in stem cell biology. In many recent discussions, observation of cell fusion has been seen as a confounding factor which calls into question published results concerning cell plasticity of, particularly, adult stem cells.
Joseph J, Lucas, Naohiro, Terada
openaire +2 more sources
Background The advances in target control of complex networks not only can offer new insights into the general control dynamics of complex systems, but also be useful for the practical application in systems biology, such as discovering new therapeutic ...
Wei-Feng Guo +5 more
doaj +1 more source

