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ViralFP: A Web Application of Viral Fusion Proteins [PDF]
Frontiers in Medical Technology, 2021 Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the ...
Pedro Moreira +5 more
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Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association
mSphere, 2018 Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time ...
Stacy R. Webb +3 more
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Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins? [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Enveloped viruses always gain entry into the cytoplasm by fusion of their lipid envelope with a cell membrane. Some enveloped viruses fuse directly with the host cell plasma membrane after virus binding to the cell receptor. Other enveloped viruses enter
A.T. Da Poian +2 more
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Viruses, 2023 The fusion of viral and cell membranes is one of the basic processes in the life cycles of viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell membrane using surface viral fusion proteins.
Sophia S. Borisevich +4 more
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Viral fusion proteins of classes II and III recognize and reorganize complex biological membranes [PDF]
Communications BiologyViral infection requires stable binding of viral fusion proteins to host membranes, which contain hundreds of lipid species. The mechanisms by which fusion proteins utilize specific host lipids to drive virus–host membrane fusion remains elusive.
Chetan S. Poojari +2 more
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Structure-Guided Design of Peptide Inhibitors Targeting Class I Viral Fusion Proteins [PDF]
PathogensViral fusion proteins are indispensable mediators of viral entry that orchestrate the fusion of viral and host membranes, making them primary targets for antiviral interventions.
Narendra Kumar Gonepudi +4 more
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Viruses, 2022 The membrane surface of enveloped viruses contains dedicated proteins enabling the fusion of the viral with the host cell membrane. Working with these proteins is almost always challenging because they are membrane-embedded and naturally metastable ...
Henriette Ebel +2 more
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Viral Membrane Fusion and the Transmembrane Domain
Viruses, 2020 Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target.
Chelsea T. Barrett, Rebecca Ellis Dutch
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Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations. [PDF]
PLoS Pathogens, 2023 Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex ...
Chi-Fei Kao +4 more
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IFITM proteins restrict viral membrane hemifusion.
PLoS Pathogens, 2013 The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li +12 more
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