PLoS Pathogens, 2023 Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex ...
Chi-Fei Kao +4 more
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SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection
Pharmaceutics, 2023 Fusion is a key event for enveloped viruses, through which viral and cell membranes come into close contact. This event is mediated by viral fusion proteins, which are divided into three structural and functional classes.
Carla Zannella +10 more
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Viruses, 2019 Fusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins.
María J. García-Murria +4 more
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Initial size and dynamics of viral fusion pores are a function of the fusion protein mediating membrane fusion [PDF]
Biology of the Cell, 2008 Background information. Protein‐mediated merger of biological membranes, membrane fusion, is an important process. To investigate the role of fusogenic proteins in the initial size and dynamics of the fusion pore (a narrow aqueous pathway, which widens to finalize membrane fusion), two different fusion proteins expressed in the same cell line were ...
Ilya, Plonsky +4 more
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Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm
Retrovirology, 2008 Enveloped viruses encode specialized fusion proteins which promote the merger of viral and cell membranes, permitting the cytosolic release of the viral cores.
Melikyan Gregory B
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Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB
Pathogens, 2021 Envelope glycoprotein (g)B is conserved throughout the Herpesviridae and mediates fusion of the viral envelope with cellular membranes for infectious entry and spread.
Melina Vallbracht +2 more
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Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion. [PDF]
PLoS ONE, 2007 The SARS coronavirus (SARS-CoV) spike is the largest known viral spike molecule, and shares a similar function with all class 1 viral fusion proteins.
Daniel R Beniac +4 more
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A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]
PLoS Pathogens, 2014 The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
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Frontiers in Microbiology, 2021 The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection.
Shuang-yong Xu +3 more
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Class II Membrane Fusion Proteins in Viral and Cellular Fusion Events [PDF]
Biophysical Journal, 2013 Class II proteins are viral membrane fusogenic molecules folded essentially as beta-sheet and having an internal fusion peptide. In particular, they lack the characteristic central alpha-helical coiled coil present in the post-fusion conformation of all other viral fusion proteins. The regular, symmetric enveloped viruses that have been studied so far,
Rey, Félix +3 more
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