Results 31 to 40 of about 221,902 (249)

Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations.

PLoS Pathogens, 2023
Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex ...
Chi-Fei Kao, Min-Hsin Tsai, Kathleen Joyce Carillo, Der-Lii Tzou, Wen Chang   +4 more
doaj   +1 more source

SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection

Pharmaceutics, 2023
Fusion is a key event for enveloped viruses, through which viral and cell membranes come into close contact. This event is mediated by viral fusion proteins, which are divided into three structural and functional classes.
Carla Zannella, Annalisa Chianese, Alessandra Monti, Rosa Giugliano, Maria Vittoria Morone, Francesco Secci, Giuseppina Sanna, Aldo Manzin, Anna De Filippis, Nunzianna Doti, Massimiliano Galdiero   +10 more
doaj   +1 more source

A Bimolecular Multicellular Complementation System for the Detection of Syncytium Formation: A New Methodology for the Identification of Nipah Virus Entry Inhibitors

Viruses, 2019
Fusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins.
María J. García-Murria, Neus Expósito-Domínguez, Gerard Duart, Ismael Mingarro, Luis Martinez-Gil   +4 more
doaj   +1 more source

Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm

Retrovirology, 2008
Enveloped viruses encode specialized fusion proteins which promote the merger of viral and cell membranes, permitting the cytosolic release of the viral cores.
Melikyan Gregory B
doaj   +1 more source

Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB

Pathogens, 2021
Envelope glycoprotein (g)B is conserved throughout the Herpesviridae and mediates fusion of the viral envelope with cellular membranes for infectious entry and spread.
Melina Vallbracht, Barbara G. Klupp, Thomas C. Mettenleiter   +2 more
doaj   +1 more source

Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion. [PDF]

PLoS ONE, 2007
The SARS coronavirus (SARS-CoV) spike is the largest known viral spike molecule, and shares a similar function with all class 1 viral fusion proteins.
Daniel R Beniac, Shauna L deVarennes, Anton Andonov, Runtao He, Tim F Booth   +4 more
doaj   +1 more source

Expression of Human ACE2 N-terminal Domain, Part of the Receptor for SARS-CoV-2, in Fusion With Maltose-Binding Protein, E. coli Ribonuclease I and Human RNase A

Frontiers in Microbiology, 2021
The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection.
Shuang-yong Xu, Alexey Fomenkov, Tien-Hao Chen, Erbay Yigit   +3 more
doaj   +1 more source

A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]

PLoS Pathogens, 2014
The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

The Mechanism of Conformational Transition and Stabilisation Strategies of Viral Membrane Fusion Proteins

Shengwu huaxue yu shengwu wuli jinzhan
Viral membrane fusion proteins facilitate the fusion of viral and host cell membranes by undergoing a transition from a prefusion conformation to a post-fusion conformation, thereby enabling the transfer of viral nucleic acids into the cell interior ...
XIE Chen-Yi, DONG Xiang-Ge, ZHAN Jiu-Yu, ZHU Hong-Wei, YU Xin, LIU Yang, YU Jia-Yu, ZHANG Xing-Xiao   +7 more
doaj   +1 more source