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Viral fusion proteins: multiple regions contribute to membrane fusion
Biochimica Et Biophysica Acta - Biomembranes, 2003 In recent years, the simple picture of a viral fusion protein interacting with the cell and/or viral membranes by means of only two localized segments (i.e. the fusion peptide and the transmembrane domain) has given way to a more complex picture in which multiple regions from the viral proteins interact with membranes.
Sérgio G Peisajovich, Yechiel Shai
exaly +3 more sources
Transient Transfection-based Fusion Assay for Viral Proteins
Bio-Protocol, 2017 Membrane fusion is vital for entry of enveloped viruses into host cells as well as for direct viral cell-to-cell spread. To understand the fusion mechanism in more detail, we use an infection free system whereby fusion can be induced by a minimal set of ...
Melina Vallbracht +3 more
doaj +4 more sources
Shielding and activation of a viral membrane fusion protein [PDF]
Nature Communications, 2018 Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these ...
Steinar Halldorsson +5 more
doaj +5 more sources
IFITM proteins restrict viral membrane hemifusion.
PLoS Pathogens, 2013 The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li +12 more
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Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins. [PDF]
J Innate Immun, 2019 Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An important component of innate immunity for identifying viruses is the family of C-type collagen-containing lectins, also known as ...
Watson A +4 more
europepmc +5 more sources
The transmembrane domain and acidic lipid flip-flop regulates voltage-dependent fusion mediated by class II and III viral proteins. [PDF]
PLoS ONE, 2013 Voltage dependence of fusion induced by class II and class III viral fusion proteins was investigated. Class II proteins from Ross River and Sindbus virus and a mutant class III protein from Epstein Barr virus were found to induce cell-cell fusion that ...
Ruben M Markosyan, Fredric S Cohen
doaj +3 more sources
The membrane fusion step of vaccinia virus entry is cooperatively mediated by multiple viral proteins and host cell components. [PDF]
PLoS Pathogens, 2011 For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate ...
Jason P Laliberte +2 more
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Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses
Frontiers in Chemistry, 2021 Membrane fusion events allow enveloped viruses to enter and infect cells. The study of these processes has led to the identification of a number of proteins that mediate this process. These proteins are classified according to their structure, which vary
Camille Lozada +5 more
doaj +1 more source
Class III Viral Membrane Fusion Proteins [PDF]
Current Opinion in Structural Biology, 2009 Accumulating structural studies of viral fusion glycoproteins have revealed unanticipated structural relationships between unrelated virus families and allowed the grouping of these membrane fusogens into three distinct classes. Here we review the newly identified group of class III viral fusion proteins, whose members include fusion proteins from ...
Marija, Backovic, Theodore S, Jardetzky
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Lipids as modulators of membrane fusion mediated by viral fusion proteins [PDF]
European Biophysics Journal, 2007 Enveloped viruses infect host cells by fusion of viral and target membranes. This fusion event is triggered by specific glycoproteins in the viral envelope. Fusion glycoproteins belong to either class I, class II or the newly described third class, depending upon their arrangement at the surface of the virion, their tri-dimensional structure and the ...
Teissier, E., Pecheur, Ei
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