Results 11 to 20 of about 221,902 (249)
Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins? [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Enveloped viruses always gain entry into the cytoplasm by fusion of their lipid envelope with a cell membrane. Some enveloped viruses fuse directly with the host cell plasma membrane after virus binding to the cell receptor. Other enveloped viruses enter
A.T. Da Poian +2 more
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IFITM proteins restrict viral membrane hemifusion.
PLoS Pathogens, 2013 The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li +12 more
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Human parainfluenza virus 3 fusion protein cleavage: a key determinant of infection and spread [PDF]
Journal of VirologyHuman parainfluenza virus 3 (HPIV3) entry into target cells depends on a viral fusion complex composed of hemagglutinin-neuraminidase (HN) and fusion protein (F).
Kyle Stearns +7 more
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Shielding and activation of a viral membrane fusion protein [PDF]
Nature Communications, 2018 Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these ...
Steinar Halldorsson +5 more
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Transient Transfection-based Fusion Assay for Viral Proteins
Bio-Protocol, 2017 Membrane fusion is vital for entry of enveloped viruses into host cells as well as for direct viral cell-to-cell spread. To understand the fusion mechanism in more detail, we use an infection free system whereby fusion can be induced by a minimal set of ...
Melina Vallbracht +3 more
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The membrane fusion step of vaccinia virus entry is cooperatively mediated by multiple viral proteins and host cell components. [PDF]
PLoS Pathogens, 2011 For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate ...
Jason P Laliberte +2 more
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Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses
Frontiers in Chemistry, 2021 Membrane fusion events allow enveloped viruses to enter and infect cells. The study of these processes has led to the identification of a number of proteins that mediate this process. These proteins are classified according to their structure, which vary
Camille Lozada +5 more
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Viral Membrane Fusion and the Transmembrane Domain
Viruses, 2020 Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target.
Chelsea T. Barrett, Rebecca Ellis Dutch
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Lipids as modulators of membrane fusion mediated by viral fusion proteins [PDF]
European Biophysics Journal, 2007 Enveloped viruses infect host cells by fusion of viral and target membranes. This fusion event is triggered by specific glycoproteins in the viral envelope. Fusion glycoproteins belong to either class I, class II or the newly described third class, depending upon their arrangement at the surface of the virion, their tri-dimensional structure and the ...
Teissier, E., Pecheur, Ei
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Viruses, 2020 Protein-mediated membrane fusion is a highly regulated biological process essential for cellular and organismal functions and infection by enveloped viruses. During viral entry the membrane fusion reaction is catalyzed by specialized protein machinery on
Mark A. Benhaim, Kelly K. Lee
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