Results 1 to 10 of about 13,921 (137)

Reconstruction of H3N2 influenza virus based virosome in-vitro

Iranian Journal of Microbiology, 2013
Background and Objectives: Virosomes are Virus Like Particles (VLP) assembled in-vitro. Influenza virosomes maintain the cell binding and membrane fusion activity of the wild type virus but are devoid of viral genetic material or internal proteins ...
Asghar Abdoli, Hoorieh Soleimanjahi, Masoumeh-Tavassoti Kheiri, Abbas Jamali, Hesam Sohani, Mohsen Abdoli, Hamid Reza Rahmatollahi   +6 more
doaj  

Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats

Virology Journal, 2008
Background Influenza virus infection or vaccination evokes an antibody response to viral hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins, which results in immunity against influenza A viruses of the same HA and NA subtype.
Ottolini Martin G, Straight Timothy M, Prince Gregory A, Eichelberger Maryna C   +3 more
doaj   +1 more source

Sulfur-containing class of broad-spectrum antivirals improves influenza virus vaccine development

Nature Communications
Enveloped viruses are significant zoonotic disease threats with the potential to cause global pandemics. We identified a class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses.
David W. Buchholz, Armando Pacheco, Sreetama Pal, I. Abrrey Monreal, Shi Xu, Brian Imbiakha, Julie Sahler, Mason Jager, Alex Liqi Lai, Erik M. Contreras, Shahrzad Ezzatpour, Brandan Cook, Elshan Ralalage, Qian Liu, Yao Yu Yeo, Andrew Ma, Haewon Byun, Obaed Shah, J. Lizbeth Reyes Zamora, Niraj K. Shil, Sara Jones-Burrage, Suzanne M. Pritchard, Chuntao Yang, Yu Zhao, Zeinab J. Mohamed, Cheyan Xu, Michael J. Jung, Gerlinde R. Van de Walle, Suchetana Mukhopadhyay, Masako Shimamura, Alan G. Goodman, Michele Hardy, Santanu Bose, Anthony V. Nicola, Jack H. Freed, Avery August, Susan Daniel, Petr Chlanda, Jace W. Jones, Ming Xian, Hector C. Aguilar   +40 more
doaj   +1 more source

Identification of Low- and High-Impact Hemagglutinin Amino Acid Substitutions That Drive Antigenic Drift of Influenza A(H1N1) Viruses.

PLoS Pathogens, 2016
Determining phenotype from genetic data is a fundamental challenge. Identification of emerging antigenic variants among circulating influenza viruses is critical to the vaccine virus selection process, with vaccine effectiveness maximized when ...
William T Harvey, Donald J Benton, Victoria Gregory, James P J Hall, Rodney S Daniels, Trevor Bedford, Daniel T Haydon, Alan J Hay, John W McCauley, Richard Reeve   +9 more
doaj   +1 more source

Cross-neutralization of Influenza A by SARS-CoV-2 specific neutralizing antibodies and polyclonal plasma: Is pre-exposure to SARS-CoV-2 protective against Influenza A?

Heliyon
According to sparse information from various countries, the seasonal influenza virus circulation has drastically decreased during the COVID-19 pandemic. Here, we show the cross-reactivity of anti-SARS-CoV-2 antibodies against influenza viruses.
Mohammad Mamun Alam, Asma Salauddin, Sayra Moni, Md Belayet Hasan Limon, Raisha Musarrat, Sagar Bosu, Mohammad Enayet Hossain, Mohammed Ziaur Rahman, Mustafizur Rahman   +8 more
doaj   +1 more source

N-glycosylation at the receptor binding site drives differences in receptor binding specificity between influenza B virus lineages

Journal of Virology
Receptor specificity plays a critical role in influenza virus host tropism and pathogenesis. Influenza A and influenza B viruses (FLUAVs and FLUBVs, respectively) utilize N-glycans with terminal sialic acids on glycoproteins decorating the surface of ...
Caroline K. Page, M. H. M. Mubassir, Pradeep Chopra, Lindsey Claire Gay, Ginger Geiger, Sean D. Ray, Justin D. Shepard, Rose J. Miller, Daniel Perez, Justin Bahl, Gerardus Josephus Boons, Stephen Mark Tompkins   +11 more
doaj   +1 more source

Low levels of influenza H5N1 HA and NA antibodies in the human population are boosted by seasonal H1N1 infection but not by H3N2 infection or influenza vaccination

mBio
An increase in the number of human cases of influenza A/H5N1 infection in the USA has raised concerns about the pandemic potential of the virus. Pre-existing population immunity is a key determinant for risk assessment and pandemic potential for any ...
Anne P. Werner, Cosette G. Schneider, Elgin H. Akin, Juliahna Hayes, Katherine Z. J. Fenstermacher, Richard E. Rothman, Lynda Coughlan, Andrew Pekosz   +7 more
doaj   +1 more source

Diagnosis Molekuler Virus Flu Burung-A Subtipe H5 Berdasarkan Amplifikasi Gen M dan H5 dengan Metode Onestep Simplex RT-PCR (MOLECULAR DIAGNOSIS OF AVIAN INFLUENZA VIRUS TYPE A AND SUBTYPE H5 BY AMPLIFICATION OF ITS M AND H5 GENES USING ONE STEP SIMPLEX R

Jurnal Veteriner, 2014
Influenza A viruses which belong to the Family of Orthomyxoviridae are a group of viruses withsegmented ssRNA genome. The viruses can be subgroupped into many subtypes on the basis of theirsurface glycoproteins, hemagglutinin (HA) and neuraminidase (NA ...
Aris Haryanto, Bibiana Krisanti, Sri Handayani Irianingsih, Dini Wahyu Yudianingtyas   +3 more
doaj  

Administration of antigenically distinct influenza viral particle combinations as an influenza vaccine strategy.

PLoS Pathogens
One approach for developing a more universal influenza vaccine is to elicit strong immune responses against canonically immunosubdominant epitopes in the surface exposed viral glycoproteins.
Xinyu Zhu, Zhaochen Luo, Rebecca A Leonard, Cait E Hamele, Rachel L Spreng, Nicholas S Heaton   +5 more
doaj   +1 more source

A new clade of H9N2 avian influenza virus circulating in Laos. [PDF]

Emerg Microbes Infect
Li J, Zhang C, Li R, Wang Y, Ullah Khan R, Quan R, Theppangna W, Bi Y.   +7 more
europepmc   +1 more source