TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins [PDF]
Autophagy ReportsSelective autophagy of the endoplasmic reticulum (ER-phagy/reticulophagy) is essential for organelle homeostasis and host defense, yet how ER quality control (ERQC) pathways distinguish viral glycoproteins from misfolded host proteins remains poorly ...
Jim Maurice Camilleri +5 more
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Assessment of pre and postinfection immunity to the hemagglutinin proteins of Influenza A(H1N1)pdm09 and Influenza A(H3N2) in India: a retrospective longitudinal study [PDF]
Virology JournalBackground Hemagglutinin (HA), one of the main surface glycoproteins of the influenza virus, is essential for viral entry into host cells. Antibodies targeting HA can neutralize the virus, offering protection against infection.
Anup Jayaram +10 more
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mBio, 2021 Since its emergence in 2009, the pandemic H1N1 influenza A virus (IAV) has caused significant disease and mortality in humans. IAVs contain two envelope glycoproteins, the receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA).
Meiling Dai +10 more
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B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat
Viruses, 2021 Antibodies are critical for providing protection against influenza virus infections. However, protective humoral immunity against influenza viruses is limited by the antigenic drift and shift of the major surface glycoproteins, hemagglutinin and ...
Jenna J. Guthmiller +2 more
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Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. [PDF]
PLoS Pathogens, 2012 The influenza virus uses the hemagglutinin (HA) and neuraminidase (NA) glycoproteins to interact with and infect host cells. While biochemical and microscopic methods allow examination of the early steps in flu infection, the genesis of progeny virions ...
Maximilian Wei-Lin Popp +2 more
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Molecules, 2022 Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of A. pseudoglehnii (APE) against influenza virus infection.
Subin Park +4 more
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Adaptation of the H7N2 Feline Influenza Virus to Human Respiratory Cell Culture
Viruses, 2022 During 2016–2017, the H7N2 feline influenza virus infected more than 500 cats in animal shelters in New York, USA. A veterinarian who had treated the cats became infected with this feline virus and showed mild respiratory symptoms. This suggests that the
Wataru Sekine +6 more
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Mucosal vaccination with recombinant adenovirus encoding nucleoprotein provides potent protection against influenza virus infection. [PDF]
PLoS ONE, 2013 Influenza vaccines that target the highly variable surface glycoproteins hemagglutinin and neuraminidase cause inconvenience of having vaccination every year.
So-Hee Kim +5 more
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SERINC5 restricts influenza virus infectivity.
PLoS Pathogens, 2022 SERINC5 is a multi-span transmembrane protein that is incorporated into HIV-1 particles in producing cells and inhibits HIV-1 entry. Multiple retroviruses like HIV-1, equine infectious anemia virus and murine leukemia virus are subject to SERINC5 ...
Fei Zhao +14 more
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Characterization of potent fusion inhibitors of influenza virus. [PDF]
PLoS ONE, 2015 New inhibitors of influenza viruses are needed to combat the potential emergence of novel human influenza viruses. We have identified a class of small molecules that inhibit replication of influenza virus at picomolar concentrations in plaque reduction ...
Michael Rowse +8 more
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