Results 31 to 40 of about 13,921 (137)

High-Yield Expression and Purification of Recombinant Influenza Virus Proteins from Stably-Transfected Mammalian Cell Lines

Vaccines, 2020
Influenza viruses infect millions of people each year, resulting in significant morbidity and mortality in the human population. Therefore, generation of a universal influenza virus vaccine is an urgent need and would greatly benefit public health ...
Jeffrey W. Ecker, Greg A. Kirchenbaum, Spencer R. Pierce, Amanda L. Skarlupka, Rodrigo B. Abreu, R. Ethan Cooper, Dawn Taylor-Mulneix, Ted M. Ross, Giuseppe A. Sautto   +8 more
doaj   +1 more source

An assembly model of Rift Valley fever virus

Frontiers in Microbiology, 2012
Rift Valley fever virus (RVFV) is a bunyavirus endemic to Africa and the Arabian Peninsula that infects humans and livestock. The virus encodes two glycoproteins, Gn and Gc, which represent the major structural antigens and are responsible for host cell ...
Mirabela eRusu, Mirabela eRusu, Richard eBonneau, Michael R Holbrook, Michael R Holbrook, Stanley J Watowich, Stefan eBirmanns, Willy eWriggers, Willy eWriggers, Alexander N Freiberg   +9 more
doaj   +1 more source

Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. [PDF]

PLoS Pathogens, 2009
Transmission of avian influenza viruses from bird to human is a rare event even though avian influenza viruses infect the ciliated epithelium of human airways in vitro and ex vivo.
Margaret A Scull, Laura Gillim-Ross, Celia Santos, Kim L Roberts, Elena Bordonali, Kanta Subbarao, Wendy S Barclay, Raymond J Pickles   +7 more
doaj   +1 more source

Bioprocess development for universal influenza vaccines based on inactivated split chimeric and mosaic hemagglutinin viruses

Frontiers in Bioengineering and Biotechnology, 2023
Seasonal influenza viruses account for 1 billion infections worldwide every year, including 3–5 million cases of severe illness and up to 650,000 deaths.
Eduard Puente-Massaguer, Annika Beyer, Madhumathi Loganathan, Iden Sapse, Juan Manuel Carreño, Juan Manuel Carreño, Goran Bajic, Weina Sun, Peter Palese, Peter Palese, Florian Krammer, Florian Krammer, Florian Krammer   +12 more
doaj   +1 more source

VIRUS-SPECIFIC HUMORAL IMMUNE RESPONSE ISOTYPIC STRUCTURE IN ADULT PATIENTS HOSPITALIZED WITH INFLUENZA A

Инфекция и иммунитет, 2016
The aim of this investigation was a comparative analysis of isotypic structure of specific antiviral systemic humoral immune response in hospitalized patients with influenza caused by virus A(H3N2) or A(H1N1), including the A(H1N1)pdm09. Paired acute and
V. Z. Krivitskaya, A. A. Vasilieva, E. M. Voytsekhovskaya, E. R. Petrova, M. M. Pisareva, Zh. V. Buzitskaya, E. A. Elpaeva, A. A. Go, L. V. Voloshchuk, N. I. Lvov, T. D. Smirnova, A. A. Sominina   +11 more
doaj   +1 more source

The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidase. [PDF]

PLoS ONE, 2012
Two glycoproteins, hemagglutinin (HA) and neuraminidase (NA), on the surface of influenza viruses play crucial roles in transfaunation, membrane fusion and the release of progeny virions.
Wentian Chen, Yaogang Zhong, Yannan Qin, Shisheng Sun, Zheng Li   +4 more
doaj   +1 more source

A novel single virus infection system reveals that influenza virus preferentially infects cells in g1 phase. [PDF]

PLoS ONE, 2013
BackgroundInfluenza virus attaches to sialic acid residues on the surface of host cells via the hemagglutinin (HA), a glycoprotein expressed on the viral envelope, and enters into the cytoplasm by receptor-mediated endocytosis.
Ryuta Ueda, Tadao Sugiura, Shinichiro Kume, Akihiko Ichikawa, Steven Larsen, Hideaki Miyoshi, Hiroaki Hiramatsu, Yasuko Nagatsuka, Fumihito Arai, Yasuo Suzuki, Yoshio Hirabayashi, Toshio Fukuda, Ayae Honda   +12 more
doaj   +1 more source

An Adenovirus-Vectored Influenza Vaccine Induces Durable Cross-Protective Hemagglutinin Stalk Antibody Responses in Mice

Viruses, 2017
Currently licensed vaccines against the influenza A virus (IAV) need to be updated annually to match the constantly evolving antigenicity of the influenza virus glycoproteins, hemagglutinin (HA), and neuramidiase (NA).
Eun Hye Kim, Gye-Yeong Han, Huan Nguyen
doaj   +1 more source

A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs

Virology Journal, 2023
Background Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines.
Vanessa Haach, Ana Paula Almeida Bastos, Danielle Gava, Francisco Noé da Fonseca, Marcos Antônio Zanella Morés, Arlei Coldebella, Ana Cláudia Franco, Rejane Schaefer   +7 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source