Results 61 to 70 of about 1,346,147 (353)

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

, 2018
Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Communicate and Fuse: How Filamentous Fungi Establish and Maintain an Interconnected Mycelial Network

Frontiers in Microbiology, 2019
Cell-to-cell communication and cell fusion are fundamental biological processes across the tree of life. Survival is often dependent upon being able to identify nearby individuals and respond appropriately.
Monika S. Fischer, N. Louise Glass, N. Louise Glass   +2 more
doaj   +1 more source

Arsenic Trioxide Promotes Tumor Progression by Inducing the Formation of PGCCs and Embryonic Hemoglobin in Colon Cancer Cells

Frontiers in Oncology, 2021
Arsenic trioxide (ATO) has been used to treat acute promyelocytic leukemia. However, it is not effective in treating solid tumors such as colorectal cancer.
Zugui Li, Minying Zheng, Hao Zhang, Xiaohui Yang, Linlin Fan, Fangmei Fu, Fangmei Fu, Junjie Fu, Junjie Fu, Rui Niu, Man Yan, Shiwu Zhang   +11 more
doaj   +1 more source

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Cell-Cell Fusion Mediated by the Fusion Protein of Ebola Virus [PDF]

Biophysical Journal, 2014
Despite the large number of infections caused by Ebolavirus (EboV), a model system for fusing cells expressing the EboV fusion glyprotein (GP) to target cells has not been developed. We have now done so. Cells expressing GP fused to target cells at neutral pH without any explicit enzymatic treatment; acidification of external solutions augmented the ...
Ruben M. Markosyan, Shan-Lu Liu, Fredric S. Cohen   +2 more
openaire   +2 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Monoclonal Antibody against Porcine LAG3 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection

Veterinary Sciences
Lymphocyte activation gene 3 (LAG3) is an inhibitory receptor and the interaction between fibrinogen-like protein 1 and LAG3 can inhibit the anti-tumor effect of T cells both in vivo and in vitro, which was regarded as a new immune evasion mechanism ...
Hui Wang, Xu Zheng, Danyang Zheng, Xiaoqian Wang, Zhiqian Zhao, Mi Zhao, Qiang Guo, Yang Mu   +7 more
doaj   +1 more source

Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction

mBio, 2019
Dendritic cells (DCs) and macrophages as well as osteoclasts (OCs) are emerging as target cells of HIV-1 involved in virus transmission, dissemination, and establishment of persistent tissue virus reservoirs. While these myeloid cells are poorly infected
Maorong Xie, Héloïse Leroy, Rémi Mascarau, Marie Woottum, Maeva Dupont, Camille Ciccone, Alain Schmitt, Brigitte Raynaud-Messina, Christel Vérollet, Jérôme Bouchet, Lucie Bracq, Serge Benichou   +11 more
doaj   +1 more source

Cell–Cell Fusion: A New Function for Invadosomes [PDF]

Current Biology, 2011
Podosomes are cytoskeletal-based structures involved in extracellular matrix remodeling and cellular motility. A new study now implicates podosomes in pore formation during myoblast fusion.
Bong Hwan Sung, Alissa M. Weaver
openaire   +3 more sources