Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]
, 2009 Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander +42 more
core +3 more sources
Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction
mBio, 2019 Dendritic cells (DCs) and macrophages as well as osteoclasts (OCs) are emerging as target cells of HIV-1 involved in virus transmission, dissemination, and establishment of persistent tissue virus reservoirs. While these myeloid cells are poorly infected
Maorong Xie +11 more
doaj +1 more source
Tumor Hybrid Cells: Nature and Biological Significance
Frontiers in Cell and Developmental Biology, 2022 Metastasis is the leading cause of cancer death and can be realized through the phenomenon of tumor cell fusion. The fusion of tumor cells with other tumor or normal cells leads to the appearance of tumor hybrid cells (THCs) exhibiting novel properties ...
Maria S. Tretyakova +4 more
doaj +1 more source
Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]
, 2015 Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J +7 more
core +2 more sources
Cell Fusion in Malignancy: A Cause or Consequence? A Provocateur or Cure?
Cells, 2019 Cell fusion has been observed in malignancy, and cancer cells have been found especially apt to fuse with other cells. Investigation of human and experimental malignancies suggests spontaneous fusion of normal cells can induce manifold genetic changes ...
Jeffrey L. Platt, Marilia Cascalho
doaj +1 more source
Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles. [PDF]
, 2015 Flaviviruses deliver their RNA genome into the host-cell cytoplasm by fusing their lipid envelope with a cellular membrane. Expression of the flavivirus pre-membrane and envelope glycoprotein genes in the absence of other viral genes results in the ...
core +1 more source
Massive NGS data analysis reveals hundreds of potential novel gene fusions in human cell lines [PDF]
, 2018 Background: Gene fusions derive from chromosomal rearrangements and the resulting chimeric transcripts are often endowed with oncogenic potential. Furthermore, they serve as diagnostic tools for the clinical classification of cancer subgroups with ...
Bolis, Marco +7 more
core +1 more source
PATH-40. A GIANT CELL LESION RESEMBLING REPARATIVE GIANT CELL GRANULOMA WITH FN1-TEK FUSION, IN THE SPECTRUM OF CALCIFIED CHONDROID MESENCHYMAL NEOPLASM? [PDF]
, 2022 Xiao–Tang Kong +4 more
openalex +1 more source
Frontiers in Oncology, 2021 Arsenic trioxide (ATO) has been used to treat acute promyelocytic leukemia. However, it is not effective in treating solid tumors such as colorectal cancer.
Zugui Li +11 more
doaj +1 more source
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells [PDF]
, 1996 To investigate the role that aging-dependent accumulation of mitochondrial DNA (mtDNA) mutations plays in the senescence processes, mitochondria from fibroblasts of 21 normal human individuals between 20 weeks (fetal) and 103 years of age were introduced
Attardi, Giuseppe +5 more
core +1 more source