Results 61 to 70 of about 1,323,463 (353)
Genetic basis of cell–cell fusion mechanisms [PDF]
Trends in Genetics, 2013 Cell-cell fusion in sexually reproducing organisms is a mechanism to merge gamete genomes and, in multicellular organisms, it is a strategy to sculpt organs, such as muscle, bone, and placenta. Moreover, this mechanism has been implicated in pathological conditions, such as infection and cancer.
Aguilar +15 more
openaire +3 more sources
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells [PDF]
, 1996 To investigate the role that aging-dependent accumulation of mitochondrial DNA (mtDNA) mutations plays in the senescence processes, mitochondria from fibroblasts of 21 normal human individuals between 20 weeks (fetal) and 103 years of age were introduced
Attardi, Giuseppe +5 more
core +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Cell-Cell Fusion Mediated by the Fusion Protein of Ebola Virus [PDF]
Biophysical Journal, 2014 Despite the large number of infections caused by Ebolavirus (EboV), a model system for fusing cells expressing the EboV fusion glyprotein (GP) to target cells has not been developed. We have now done so. Cells expressing GP fused to target cells at neutral pH without any explicit enzymatic treatment; acidification of external solutions augmented the ...
Ruben M. Markosyan +2 more
openaire +2 more sources
eLifeThe bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cells – generated ...
Evgenia Leikina +5 more
doaj +1 more source
The Journal of Poultry Science, 2005 In order to produce nuclear transferred PGCs, fusion of primordial germ cell (PGC) with embryonic blood cell (EBC) was attempted. PGCs and EBCs were isolated from the blood of stages 13-15 embryos.
Mitsuru Naito +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to injured cells, leading to increased
Marina O. Gomzikova +5 more
doaj +1 more source
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
, 2018 Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core +1 more source
Fusion of neurohypophyseal membranes in vitro [PDF]
, 1977 Freeze cleaving electron microscopy has shown that fusion of isolated secretory vesicles from bovine neurohypophyses was induced by Ca 2+ in micromolar concentrations. Mg 2+ and Sr 2+ were ineffective. Mg 2+ inhibited Ca 2+-induced fusion. In suspensions
Dahl, G. +3 more
core +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source