Results 101 to 110 of about 11,093,569 (425)

Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsets

Scientific Reports
Obstructive sleep apnea syndrome (OSAS) and obesity go hand in hand in the majority of patients and both are associated with a systemic inflammation, immune disturbance and comorbidities such as cardiovascular disease.
Ralph Pries, Friederike Katharina Kosyna, Reinhard Depping, Kirstin Plötze-Martin, Christian Lange, Svenja Meyhöfer, Sebastian M. Meyhöfer, Jens U. Marquardt, Karl-Ludwig Bruchhage, Armin Steffen   +9 more
doaj   +1 more source

Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma

Tumor Biology, 2017
To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data.
Maisa Ribeiro, Sarah R Teixeira, Monarko N Azevedo, Ailton C Fraga Jr, Antônio PM Gontijo, Eneida F Vêncio   +5 more
doaj   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Hypoxia and Regulation of Cancer Cell Stemness [PDF]

, 2013
Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell "stemness." Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic capabilities are identified, suggesting that the tumor microenvironment can exert a significant ...
Zhong Yun, Qun Lin
openaire   +3 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition

Journal of Orthopaedic Translation, 2022
Background: /Objective: Biological factors such as platelet-rich plasma (PRP) combined with anterior cruciate ligament (ACL) primary repair technology are used to treat ACL injury.
Yanwei Cao, Yue Li, Sai Chuen Fu, Jiewei Shen, Hui Zhang, Chunyan Jiang, Patrick Shu-Hang Yung   +6 more
doaj  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Cell line development for continuous high cell density biomanufacturing: Exploiting hypoxia for improved productivity

Metabolic Engineering Communications, 2021
Oxygen deficiency (hypoxia) induces adverse effects during biotherapeutic protein production leading to reduced productivity and cell growth. Hypoxic conditions occur during classical batch fermentations using high cell densities or perfusion processes ...
Nikolas Zeh, Patrick Schlossbauer, Nadja Raab, Florian Klingler, René Handrick, Kerstin Otte   +5 more
doaj  

A flux-limited model for glioma patterning with hypoxia-induced angiogenesis [PDF]

arXiv, 2020
We propose a model for glioma patterns in a microlocal tumor environment under the influence of acidity, angiogenesis, and tissue anisotropy. The bottom-up model deduction eventually leads to a system of reaction-diffusion-taxis equations for glioma and endothelial cell population densities, of which the former infers flux limitation both in the self ...
arxiv