Results 91 to 100 of about 375,784 (265)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

CoCl₂-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors. [PDF]

Biomedicines, 2022
Kutryb-Zajac B, Kawecka A, Braczko A, Franczak M, Slominska EM, Giovannoni R, Smolenski RT.   +6 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Radiation and chemotherapy variable response induced by tumor cell hypoxia: impact of radiation dose, anticancer drug, and type of cancer. [PDF]

Radiat Environ Biophys, 2022
Ibrahim AM, Nady S, Shafaa MW, Khalil MM.   +3 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma

Clinical and Translational Medicine, 2019
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune cells including cytotoxic T cells; however ...
S. K. Daniel, K. M. Sullivan, K. P. Labadie, V. G. Pillarisetty   +3 more
doaj   +1 more source

Generalizable synthesis of bioresponsive near-infrared fluorescent probes: sulfonated heptamethine cyanine prototype for imaging cell hypoxia. [PDF]

Org Biomol Chem, 2021
Atkinson KM, Morsby JJ, Kommidi SSR, Smith BD.   +3 more
europepmc   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Phosphorescence-based O2 sensing reveals size-dependent survival and motility of metastatic prostate cancer cells in self-generated hypoxia

iScience
Summary: Cancer cells in solid tumors experience hypoxia, a condition of low O2 concentration, since their O2 demand exceeds the supply from the surrounding vasculature. However, how these cells adapt to hypoxia requires further elucidation. Here, we use
Noreen Hosny, Kimberly Shen, Yihua Zhao, Junle Qu, Yusha Sun, George Butler, Sarah Amend, Emma U. Hammarlund, Robert Gatenby, Joel Brown, Kenneth J. Pienta, Trung V. Phan, Stephano Boyer-Paulet, Shengkai Li, Robert H. Austin   +14 more
doaj   +1 more source

MicroRNA-133b Alleviates Hypoxia Injury by Direct Targeting on NOD-Like Receptor Protein 3 in Rat H9c2 Cardiomyocyte

Cardiology Research and Practice, 2019
Objective. MiR-133b was dysregulated in myocardial infarction. However, the role and mechanism of miR-133b in myocardial infarction remains unclear.
Yongmei Zhou, Hui Huang, Xiaolin Hou
doaj   +1 more source