Results 21 to 30 of about 349,615 (316)
Experimental Cell Research, 2017 The ability of cells to sense and adapt to changes in oxygen is mediated by hypoxia-inducible factor (HIF). Immune cells function in physiologically complex and varying environments whereby oxygen, pH, nutrients, metabolites and cytokines are continuously fluctuating.
Burrows, N, Maxwell, PH
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NK cells, hypoxia and trophoblast cell differentiation [PDF]
Cell Cycle, 2012 Hemochorial placentation is characterized by extensive remodeling of the maternal vasculature, converting them to flaccid low resistance vessels. This process greatly facilitates exchange of nutrients and gases between the mother and the fetus. Two key modulators that orchestrate these vascular changes have been identified at the maternal fetal ...
Damayanti Chakraborty +2 more
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Biomédica: revista del Instituto Nacional de Salud, 2017 Introducción. El microambiente tumoral influye en el comportamiento de las células cancerosas. Especialmente, el estímulo de agentes estresantes, como la hipoxia, se convierte en un factor crítico para la evolución y el tratamiento del cáncer.
Óscar Ortega +2 more
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Hypoxia and metabolic adaptation of cancer cells [PDF]
Oncogenesis, 2016 AbstractLow oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus that metazoan organisms have contended with since they evolved from their single-celled ancestors. The effect of hypoxia on a tissue can be either positive or negative, depending on the severity, duration and context.
Katherine L. Eales +3 more
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Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications
Frontiers in Oncology, 2021 Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is often associated with a more aggressive phenotype, increased risk of ...
Ying Zhang +13 more
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GAS5 silencing attenuates hypoxia‐induced cardiomyocytes injury by targeting miR‐21/PTEN
Immunity, Inflammation and Disease, 2023 Introduction Myocardial hypoxia is an important factor causing myocardial infarction (MI). Interestingly, many unknown factors in the molecular mechanism of MI remain unclear.
Qianli Wang, Zan Xie
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Biology, 2023 Bone formation is driven by many signaling molecules including bone morphogenetic protein 9 (BMP-9) and hypoxia-inducible factor 1-alpha (HIF-1α). We demonstrated that cell therapy using mesenchymal stem cells (MSCs) overexpressing BMP-9 (MSCs+BMP-9 ...
Jessica Emanuella Rocha Moura Paz +8 more
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Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. [PDF]
PLoS ONE, 2012 Hypoxia plays a critical role in coordinating cell survival, differentiation and death in normal embryogenesis; during limb pattern formation, hypoxia affects two key processes, chondrogenesis and cell death.
Chunwei Huang, Barbara F Hales
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Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. [PDF]
PLoS ONE, 2014 B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity.
Sebastian Fischer +11 more
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