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Hypoxia and cancer cell metabolism [PDF]
Acta Biochimica et Biophysica Sinica, 2014 The past decade has witnessed a rapid accumulation of evidence showing that hypoxic microenvironment, which is typical during cancer development, plays key roles in regulating cancer cell metabolism. In this review, we will focus on the role of hypoxic response, particularly, its master regulator hypoxia-inducible factor-1, in regulating glucose, lipid,
Huafeng Zhang, Chenchen Li, De Huang
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Mast cell survival and mediator secretion in response to hypoxia. [PDF]
PLoS ONE, 2010 Tissue hypoxia is a consequence of decreased oxygen levels in different inflammatory conditions, many associated with mast cell activation. However, the effect of hypoxia on mast cell functions is not well established.
Magdalena Gulliksson +3 more
doaj +1 more source
Frontiers in Oncology, 2021 AimsTo reveal the influence of hypoxia on tumor cells and immune cells in primary IDH-wt glioblastoma patients.MethodsSingle-cell RNA-seq data and bulk RNA-seq data were acquired from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA ...
Zujian Xiong +8 more
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Journal of Translational Medicine, 2023 Background The 5-year survival rate of patients with head and neck squamous cell carcinoma (HNSCC) remains
Cong Peng +5 more
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Global gene expression profiling in three tumor cell lines subjected to experimental cycling and chronic hypoxia. [PDF]
PLoS ONE, 2014 Hypoxia is one of the most important features of the tumor microenvironment, exerting an adverse effect on tumor aggressiveness and patient prognosis.
Magdalena Olbryt +5 more
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Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]
, 2020 Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles +3 more
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Impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development [PDF]
Cells 9(3), 733, 2020, 2020 Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood.
arxiv +1 more source
The role of tumour suppressor PDCD4 in beta cell death in hypoxia. [PDF]
PLoS ONE, 2017 Hypoxia is known to induce pancreatic beta cell dysfunction and apoptosis. Changes in Programmed Cell Death Gene 4 (PDCD4) expression have previously been linked with beta cell neogenesis and function. Our aim was to investigate the effects of hypoxia on
Sandeep Kumar +4 more
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Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]
, 2020 High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ +9 more
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Induction and Testing of Hypoxia in Cell Culture [PDF]
Journal of Visualized Experiments, 2011 Hypoxia is defined as the reduction or lack of oxygen in organs, tissues, or cells. This decrease of oxygen tension can be due to a reduced supply in oxygen (causes include insufficient blood vessel network, defective blood vessel, and anemia) or to an increased consumption of oxygen relative to the supply (caused by a sudden higher cell proliferation ...
Patricia Yotnda, Danli Wu
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