Results 31 to 40 of about 375,784 (265)
Hypoxia, stem cells and bone tumor [PDF]
Cancer Letters, 2011 Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors.
Wen, Zeng +4 more
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Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. [PDF]
PLoS ONE, 2014 B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity.
Sebastian Fischer +11 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin‐1 gene, which encodes the extracellular matrix protein fibrillin‐1.
Yuhao Chen +12 more
doaj +1 more source
Frontiers in Physiology, 2017 Background : Hypoxia inducible factor 1 alpha (HIF1A) is a master regulator of acute hypoxia; however, with chronic hypoxia, HIF1A levels return to the normoxic levels.
Eugenia Mata-Greenwood +4 more
doaj +1 more source
The impact of hypoxia on B cells in COVID-19
EBioMedicine, 2022 Summary: Background: Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2.
Prasanti Kotagiri +21 more
doaj +1 more source
Hypoxia, Metabolism and Immune Cell Function [PDF]
Biomedicines, 2018 Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key mediators of the cellular response to hypoxia, but they are also associated with pathological stress such as inflammation, bacteriological infection or cancer.
Krzywinska, Ewelina +1 more
openaire +3 more sources
Hypoxia and Regulation of Cancer Cell Stemness [PDF]
, 2013 Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell "stemness." Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic capabilities are identified, suggesting that the tumor microenvironment can exert a significant ...
Zhong, Yun, Qun, Lin
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Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To analyze the protective effect and mechanism of nuclear factor⁃erythroid 2⁃related factor 2 (Nrf2) signal pathway agonist tertiary butylhydroquinone (tBHQ) on astrocytes under oxygen glucose deprivation (OGD).
GAO Yu⁃tian +3 more
doaj +1 more source
Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence
Cells, 2021 Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment ...
Apostolos Menegakis +9 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source