Results 21 to 30 of about 375,784 (265)
Journal of Orthopaedic Translation, 2022 Background: /Objective: Biological factors such as platelet-rich plasma (PRP) combined with anterior cruciate ligament (ACL) primary repair technology are used to treat ACL injury.
Yanwei Cao +6 more
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Induction and Testing of Hypoxia in Cell Culture [PDF]
Journal of Visualized Experiments, 2011 Hypoxia is defined as the reduction or lack of oxygen in organs, tissues, or cells. This decrease of oxygen tension can be due to a reduced supply in oxygen (causes include insufficient blood vessel network, defective blood vessel, and anemia) or to an increased consumption of oxygen relative to the supply (caused by a sudden higher cell proliferation ...
Danli, Wu, Patricia, Yotnda
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Biomédica: revista del Instituto Nacional de Salud, 2017 Introducción. El microambiente tumoral influye en el comportamiento de las células cancerosas. Especialmente, el estímulo de agentes estresantes, como la hipoxia, se convierte en un factor crítico para la evolución y el tratamiento del cáncer.
Óscar Ortega +2 more
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Metabolic Engineering Communications, 2021 Oxygen deficiency (hypoxia) induces adverse effects during biotherapeutic protein production leading to reduced productivity and cell growth. Hypoxic conditions occur during classical batch fermentations using high cell densities or perfusion processes ...
Nikolas Zeh +5 more
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Frontiers in Bioscience-Landmark, 2021 Objective: Nucleus pulposus cells (NPCs) are cells extracted from the intervertebral disc and are important for research into intervertebral disc degeneration (IVDD). NPCs live in an avascular and relatively hypoxic environment.
Xiao-Xin Gao +8 more
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Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications
Frontiers in Oncology, 2021 Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is often associated with a more aggressive phenotype, increased risk of ...
Ying Zhang +13 more
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GAS5 silencing attenuates hypoxia‐induced cardiomyocytes injury by targeting miR‐21/PTEN
Immunity, Inflammation and Disease, 2023 Introduction Myocardial hypoxia is an important factor causing myocardial infarction (MI). Interestingly, many unknown factors in the molecular mechanism of MI remain unclear.
Qianli Wang, Zan Xie
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Biology, 2023 Bone formation is driven by many signaling molecules including bone morphogenetic protein 9 (BMP-9) and hypoxia-inducible factor 1-alpha (HIF-1α). We demonstrated that cell therapy using mesenchymal stem cells (MSCs) overexpressing BMP-9 (MSCs+BMP-9 ...
Jessica Emanuella Rocha Moura Paz +8 more
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Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. [PDF]
PLoS ONE, 2012 Hypoxia plays a critical role in coordinating cell survival, differentiation and death in normal embryogenesis; during limb pattern formation, hypoxia affects two key processes, chondrogenesis and cell death.
Chunwei Huang, Barbara F Hales
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Apoptotic Cell Death Under Hypoxia
Physiology, 2014 Eukaryotic life depends largely on molecular oxygen. During evolution, ingenious mechanisms have evolved that allow organisms to adapt when oxygen levels decrease. Many of these adaptional responses to low oxygen are orchestrated by the heterodimeric transcription factor hypoxia-inducible factor (HIF). Here, we review the link between HIF and apoptosis.
Sendoel Ataman, Hengartner Michael O
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