Results 301 to 310 of about 619,300 (360)

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Hypoxia as a Central Regulator of Plasma Membrane Phosphohydrolase Enzymes: Possible Roles in Extracellular Phosphate Generation and Adenosine Metabolism. [PDF]

Membranes (Basel)
de Oliveira PHS, Silva-Freitas BB, Meyer-Fernandes JR, Lacerda-Abreu MA.   +3 more
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Single-cell and transcriptomic profiling reveal stemness-driven immune evasion in obstructive sleep apnea (OSA) associated lung cancer. [PDF]

J Cancer
Liu YW, Wu CJ, Chang KF, Lee YK, Lin HR, Ko CC, Hsieh CB, Chang CH, Lin CH, Chen BS, Solomon DD, Kumar S, Palekkode N, Fathima A, Xuan DTM, Nguyen NUN, Waikhom J, Yuan CH, Wu YJ.   +18 more
europepmc   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Hypoxia-induced oxidative stress and mitochondrial damage initiate ferroptosis in Cryptocaryon irritans, a protozoan parasite of marine fish. [PDF]

Stress Biol
Wang B, Luo Z, Zhuang J, Li Z, Lai X, Wu H, Han Q, Cao J, Wang H, Dong C, Li A.   +10 more
europepmc   +1 more source

Enhancing the efficacy of VEGF inhibitors by co-inhibition of HIF in the treatment of glioblastoma. [PDF]

Apoptosis
Harbi E, Byrne YY, Bozbey HU, Tastekin D, Oncul O, Hosseiny S, Yahya D, Yildiz O, Erdogan M, Slocum AK, Mason CE, Aschner M.   +11 more
europepmc   +1 more source

Global characterization of Dictyostelium discoideum gene and protein expression changes under hypoxic conditions. [PDF]

BMC Genomics
Hesnard J, Gas-Pascual E, van der Wel H, Cochet-Escartin O, Joly S, Rieu JP, West CM, Anjard C.   +7 more
europepmc   +1 more source

Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis. [PDF]

Oncol Rep
Ichihara T, Hayashi Y, Sato T, Iguchi M, Toi M, Satake H, Murakami I.   +6 more
europepmc   +1 more source