Results 311 to 320 of about 619,300 (360)

Hypoxia-triggered autophagy modulates cisplatin resistance in non-small cell lung Cancer via EIF2AK3-dependent PI3K/AKT signaling and mTOR-independent mechanisms. [PDF]

Cell Death Discov
Fu J, Xu W, Wang G, Zeng L, Xian L, Wei Y, Zhang J.   +6 more
europepmc   +1 more source

Ginsenoside potential targeting hypoxia-inducible factor-1α as promising therapeutics for cancer: a review. [PDF]

Front Med (Lausanne)
Ai X, Li A, Feng R, Xu H, Yue H, Wang Z, Dai Y.   +6 more
europepmc   +1 more source

Hypoxia-regulatable CAR T cells

Molecular Therapy
openaire   +2 more sources

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Apoptotic Cell Death Under Hypoxia

Physiology, 2014
Eukaryotic life depends largely on molecular oxygen. During evolution, ingenious mechanisms have evolved that allow organisms to adapt when oxygen levels decrease. Many of these adaptional responses to low oxygen are orchestrated by the heterodimeric transcription factor hypoxia-inducible factor (HIF). Here, we review the link between HIF and apoptosis.
Sendoel Ataman, Hengartner Michael O
openaire   +3 more sources

Intermittent hypoxia: cell to system

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
This symposium was organized to present research dealing with the effects of intermittent hypoxia on cardiorespiratory systems and cellular mechanisms. The pattern of neural impulse activity has been shown to be critical in the induction of genes in neuronal cells and involves distinct signaling pathways.
N R, Prabhakar, R D, Fields, T, Baker, E C, Fletcher   +3 more
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Cerebral cell population under hypoxia

The Anatomical Record, 1966
AbstractThree pregnant albino Sprague‐Dawley rats were subjected to simulated high altitudes of 18,000 feet (365 mm Hg) in low pressure chambers during their entire pregnancy. The brains of the newborn rats were removed immediately after birth and placed in 10% formalin.
R R, Shivers, P G, Roofe
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Cell-Autonomous Metabolic Reprogramming in Hypoxia

Trends in Cell Biology, 2018
Molecular oxygen (O2) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoans. Consequently, hypoxia (low O2) has arisen as an organizing principle for cellular evolution, metabolism, and (patho)biology, eliciting a remarkable panoply of metabolic adaptations that trigger transcriptional ...
Luana Schito, Sergio Rey
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Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance

2010
Hypoxia promotes tumor progression through multiple mechanisms including modifying angiogenesis, metabolism switch and invasion. Hypoxia inducible factors (HIFs), particularly HIF1α and HIF2α, are key mediators in cancer hypoxia response and high expression levels of HIFs correlate with a poor prognosis in various tumor types. Cancer stem cells (CSCs),
Zhizhong, Li, Jeremy N, Rich
openaire   +2 more sources