Results 321 to 330 of about 619,300 (360)

Hypoxia, reactive oxygen, and cell injury

Free Radical Biology and Medicine, 1989
Hypoxia usually decreases the formation of reactive oxygen species by oxidases and by autoxidation of components of cellular electron transfer pathways and of quinoid compounds such as menadione. In the case of menadione reactive oxygen species are liberated to a significant extent only at non-physiologically high oxygen partial pressures (PO2).
H, de Groot, A, Littauer
openaire   +2 more sources

Stem Cells, Hypoxia and Hypoxia-Inducible Factors

2009
Oxygen is a critical environmental factor that regulates the fate of stem cells. In this review, our aims are twofold: (i) to consider the contribution of oxygen tension to the environmental niches in which stem cells and their progeny find themselves and which have a role in determining their fate, and (ii) to define the regulatory networks that ...
Suzanne M. Watt, Grigorios Tsaknakis, Sinead P. Forde, Lee Carpenter   +3 more
openaire   +1 more source

Cancer Stem Cells, Hypoxia and Metastasis

Seminars in Radiation Oncology, 2009
The successful growth of a metastasis, by definition, requires the presence of at least 1 cancer stem cell. Metastasis is a complex process, and an important contributor to this process is the influence of the tissue microenvironment, both cell-cell and cell-matrix interactions and the pathophysiologic conditions in tumors, such as hypoxia. A number of
Richard P, Hill, Delphine T, Marie-Egyptienne, David W, Hedley   +2 more
openaire   +2 more sources

Hypoxia-induced dedifferentiation in neuroblastoma cells

Cancer Letters, 2003
Hypoxia in solid tumors is associated with aggressive behavior and poor outcome. We recently discovered that hypoxia alters the expression of differentiation marker genes in neuroblastoma cells, in that the tumor cells adjust to the hypoxic environment by down-regulating genes associated with a neuronal and upregulating genes associated with a neural ...
Annika, Jögi, Ingrid, Øra, Helen, Nilsson, Lorenz, Poellinger, Håkan, Axelson, Sven, Påhlman   +5 more
openaire   +2 more sources

Hypoxia Tolerance of Coronary Endothelial Cells

1990
The coronary endothelium performs a great number of specific metabolic and physiological functions, e.g. the synthesis of autacoids, and the control of the transport of material into and out of the blood stream. For these performances a sufficient supply of metabolic energy is required. Alterations of the energetic state, e.g. due to an insufficient O2
T, Noll, P, Wissemann, S, Mertens, A, Krützfeldt, R, Spahr, H M, Piper   +5 more
openaire   +2 more sources

In vitro intermittent hypoxia: challenges for creating hypoxia in cell culture

Respiratory Physiology & Neurobiology, 2003
Intermittent hypoxia has been implicated in morbidities associated with sleep apnea, and may be a novel cellular signal for inflammation [J. Appl. Physiol. 90 (2001) 1986]. Standard cell culture has two major limitations for studying the effects of steady-state P(O(2)) and intermittent hypoxia.
James E, Baumgardner, Cynthia M, Otto
openaire   +2 more sources

Culture media from hypoxia conditioned endothelial cells protect human intestinal cells from hypoxia/reoxygenation injury

Experimental Cell Research, 2014
Remote ischemic preconditioning (RIPC) is a phenomenon, whereby short episodes of non-lethal ischemia to an organ or tissue exert protection against ischemia/reperfusion injury in a distant organ. However, there is still an apparent lack of knowledge concerning the RIPC-mediated mechanisms within the target organ and the released factors.
Lars, Hummitzsch, Karina, Zitta, Berthold, Bein, Markus, Steinfath, Martin, Albrecht   +4 more
openaire   +2 more sources

Barbiturates Protect Retinal Cells from Hypoxia in Cell Culture

Archives of Ophthalmology, 1989
A culture system was used to screen for drugs that can protect mammalian retinal cells from damage induced by hypoxia. Using a special incubator, cultures could be made hypoxic for defined periods. Phase contrast photomicroscopy facilitated comparison of retinal cells before hypoxia and 1 to 2 days after hypoxia.
J S, Pulido, M, Fukuda, C A, Howe, D G, Puro   +3 more
openaire   +2 more sources

Hypoxia, Hypoxia-Inducing Factor-1 and Leukemic Cell Differentiation

SCIENTIA SINICA Vitae, 2014
Hypoxia-inducible factor-1 (HIF-1), a master transcriptional factor for cellular response to hypoxia, consists of hypoxia-sensitive HIF-1a and constitutively expressed HIF-1b. Studies showed that HIF-1 plays an important role in the progression and metastasis of solid tumors because hypoxia is regarded as a key microenvironment of cancer.
openaire   +1 more source

Hypoxia regulates the hematopoietic stem cell niche

Pflügers Archiv - European Journal of Physiology, 2015
Bone marrow, the site of hematopoiesis throughout adulthood, is a physiologically hypoxic organ. Thus, various biological oxygen sensors and their signaling cascades play a pivotal role in hematopoietic systems in the bone marrow under both physiologic and pathologic conditions.
Takayuki, Morikawa, Keiyo, Takubo
openaire   +2 more sources