Results 31 to 40 of about 349,615 (316)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin‐1 gene, which encodes the extracellular matrix protein fibrillin‐1.
Yuhao Chen +12 more
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Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence
Cells, 2021 Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment ...
Apostolos Menegakis +9 more
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Frontiers in Physiology, 2017 Background : Hypoxia inducible factor 1 alpha (HIF1A) is a master regulator of acute hypoxia; however, with chronic hypoxia, HIF1A levels return to the normoxic levels.
Eugenia Mata-Greenwood +4 more
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Bovine milk exosomes affected proliferation of macrophages under hypoxia
Current Research in Food Science, 2022 Exosomes are extracellular vesicles implicated in cell-to-cell communication. The objective was to investigate the effect of exosomes in macrophages under hypoxia.
Svjetlana Matic, Vermont P. Dia
doaj
Cancer Medicine, 2023 Background Hypoxia is commonly characterized by malignant tumors that promote the aggressiveness and metastatic potential of cancer. Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with approximately 46% capacity ...
Thi My Hang Nguyen +5 more
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Molecular responses to hypoxia in tumor cells.
Molecular cancer, 2003 Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of influences on tumor cell biology. Among these are activation of certain signal transduction pathways and gene regulatory mechanisms, induction of ...
Saleh M. Ibrahim, Manfred Kunz
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Hypoxia, stem cells and bone tumor [PDF]
Cancer Letters, 2011 Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors.
Yiyong Wei +4 more
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Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To analyze the protective effect and mechanism of nuclear factor⁃erythroid 2⁃related factor 2 (Nrf2) signal pathway agonist tertiary butylhydroquinone (tBHQ) on astrocytes under oxygen glucose deprivation (OGD).
GAO Yu⁃tian +3 more
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Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells [PDF]
ClinicsOBJECTIVES: Hypoxia leads to endothelial cell inflammation, apoptosis, and damage, which plays an important role in the complications associated with ischemic cardiovascular disease.
Xiaohui Zhou +5 more
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