GAS5 silencing attenuates hypoxia‐induced cardiomyocytes injury by targeting miR‐21/PTEN
Immunity, Inflammation and Disease, 2023 Introduction Myocardial hypoxia is an important factor causing myocardial infarction (MI). Interestingly, many unknown factors in the molecular mechanism of MI remain unclear.
Qianli Wang, Zan Xie
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Vascular changes in the rat brain during chronic hypoxia in the presence and absence of hypercapnia. [PDF]
, 2005 Changes in brain vascularity in adult rats during adaptation to chronic normobaric hypoxia with or without elevated CO(2) were morphometrically investigated.
Hayashida, Yoshiaki +6 more
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Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body [PDF]
, 2017 Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade.
Annese, Valentina +3 more
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Theranostics, 2018 Exosomes (Exo) secreted from hypoxia-conditioned bone marrow mesenchymal stem cells (BM-MSCs) were found to be protective for ischemic disease. However, the role of exosomal miRNA in the protective effect of hypoxia-conditioned BM-MSCs-derived Exo (Hypo ...
Ling-Ping Zhu +13 more
semanticscholar +1 more source
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. [PDF]
PLoS ONE, 2012 Hypoxia plays a critical role in coordinating cell survival, differentiation and death in normal embryogenesis; during limb pattern formation, hypoxia affects two key processes, chondrogenesis and cell death.
Chunwei Huang, Barbara F Hales
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Biology, 2023 Bone formation is driven by many signaling molecules including bone morphogenetic protein 9 (BMP-9) and hypoxia-inducible factor 1-alpha (HIF-1α). We demonstrated that cell therapy using mesenchymal stem cells (MSCs) overexpressing BMP-9 (MSCs+BMP-9 ...
Jessica Emanuella Rocha Moura Paz +8 more
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Deep learning-based detection of morphological features associated with hypoxia in H&E breast cancer whole slide images [PDF]
arXiv, 2023 Hypoxia occurs when tumour cells outgrow their blood supply, leading to regions of low oxygen levels within the tumour. Calculating hypoxia levels can be an important step in understanding the biology of tumours, their clinical progression and response to treatment. This study demonstrates a novel application of deep learning to evaluate hypoxia in the
arxiv
Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. [PDF]
PLoS ONE, 2014 B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity.
Sebastian Fischer +11 more
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On the Treatment of Melanoma: A Mathematical Model of Oncolytic Virotherapy [PDF]
, 2023 We develop and analyze a mathematical model of oncolytic virotherapy in the treatment of melanoma. We begin with a special, local case of the model, in which we consider the dynamics of the tumour cells in the presence of an oncolytic virus at the primary tumour site.
arxiv +1 more source
Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]
, 2012 The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
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