Results 71 to 80 of about 599,693 (212)
Stem Cells International, 2022 Hypoxia-mimetic agents are new potential tools in MSC priming instead of hypoxia incubators or chambers. Several pharmaceutical/chemical hypoxia-mimetic agents can be used to induce hypoxia in the tissues: deferoxamine (DFO), dimethyloxaloylglycine (DMOG)
Agata Nowak-Stępniowska +3 more
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BMC BiotechnologyHypoxia is a key feature of the tumor microenvironment, and can promote tumor progression. FOXD1 has been found to be involved in several types of cancer; however, its role in mediating cancer cell growth under hypoxia conditions is unclear.
Jing Gao, Shuang Wu
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Artificial Cells, Nanomedicine, and BiotechnologyHypoxia-induced brain damage can cause consciousness, memory failure and death. HK2 and TPI1 were investigated to see how they change hypoxia sensitivity in neurons and non-neurons.
Rehana Ismail +10 more
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A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2
Journal of Biological Engineering, 2018 Background While hypoxia has been well-studied in various tumor microenvironments, its role in cancer cell dormancy is poorly understood, in part due to a lack of well-established in vitro and in vivo models. Hypoxic conditions under conventional hypoxia
Hak Rae Lee +2 more
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Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]
, 2018 17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie +6 more
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Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. [PDF]
, 2018 Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the levels of multiple cell surface or intracellular
Chang, Howard Y +8 more
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Glioblastoma, Cancer Stem Cells and Hypoxia
Brain Pathology, 2010 AbstractGlioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease within 1 or 2 years of diagnosis. Recent studies have suggested that many solid tumors, including GBM, are maintained by a subset of cells termed cancer stem cells (CSCs). It has been shown that these cells are inherently radio‐ and chemotherapy resistant, and
openaire +3 more sources
Role of glycosylation in hypoxia-driven cell migration and invasion
Cell Adhesion & Migration, 2019 Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit.
Cecilia Arriagada +2 more
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Molecular OncologyTumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head and neck squamous cell carcinoma (HNSCC). To effectively target hypoxia, therapies require selection biomarkers and preclinical models that can accurately model ...
Tet Woo Lee +11 more
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Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors
Cell Reports, 2019 Summary: Hypoxia plays a major role in the physiology of hematopoietic and immune niches. Important clues from works in mouse have paved the way to investigate the role of low O2 levels in hematopoiesis. However, whether hypoxia impacts the initial steps
Sara Chabi +9 more
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