Results 71 to 80 of about 11,093,569 (425)

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors

Nature Cell Biology, 2018
As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell proliferation1–4. However, the limiting metabolites for proliferation under hypoxia and in tumours are unknown.
J. Garcia-Bermudez, Lou Baudrier, Konnor C. La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, T. Papagiannakopoulos, H. Molina, M. Snuderl, C. Lewis, Richard L. Possemato, Kıvanç Birsoy   +11 more
semanticscholar   +1 more source

Bovine milk exosomes affected proliferation of macrophages under hypoxia

Current Research in Food Science, 2022
Exosomes are extracellular vesicles implicated in cell-to-cell communication. The objective was to investigate the effect of exosomes in macrophages under hypoxia.
Svjetlana Matic, Vermont P. Dia
doaj  

Adenosine, ‘pertussis-sensitive’ G-proteins, and K+ conductance in central mammalian neurones under energy deprivation [PDF]

, 1989
There is a striking similarity between the effects of adenosine and of hypoxia or glucose depletion on membrane potential and conductance of hippocampal neurones in tissue slices of rat brain.
A. Spuler, Aghajanian, Andrade, Deuticke, Fredholm, Fujiwara, Glötzner, Godfraind, Greene, Hagberg, Hansen, Isenberg, P. Grafe, Segal, Siggins, Spuler   +15 more
core   +1 more source

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Journal of Clinical Investigation, 2018
Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the ...
P. Jayaprakash, Midan Ai, Arthur J Liu, Pratha Budhani, T. Bartkowiak, Jie Sheng, C. Ager, C. Nicholas, A. Jaiswal, Yanqiu Sun, Krishna Shah, S. Balasubramanyam, Nan Li, Guocan Wang, Jing Ning, A. Zal, T. Zal, M. Curran   +17 more
semanticscholar   +1 more source

Hypoxia‐induced YAP activation and focal adhesion turnover to promote cell migration in mesenchymal TNBC cells

Cancer Medicine, 2023
Background Hypoxia is commonly characterized by malignant tumors that promote the aggressiveness and metastatic potential of cancer. Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with approximately 46% capacity ...
Thi My Hang Nguyen, Yi‐Shyun Lai, Ying‐Chi Chen, Tzu‐Chien Lin, Ngoc Thang Nguyen, Wen‐Tai Chiu   +5 more
doaj   +1 more source

Targeting Hypoxia to Improve Non–Small Cell Lung Cancer Outcome

Journal of the National Cancer Institute, 2018
Oxygen deprivation (hypoxia) in non-small cell lung cancer (NSCLC) is an important factor in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target, particularly in the context of radiotherapy, which is delivered to more than
A. Salem, M. Asselin, B. Reymen, A. Jackson, P. Lambin, C. West, J. O’Connor, C. Faivre-Finn   +7 more
semanticscholar   +1 more source

Hypoxia, stem cells and bone tumor [PDF]

Cancer Letters, 2011
Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors.
Yiyong Wei, Yuehuan Zheng, Shree Ram Singh, Rong Wan, Wen Zeng   +4 more
openaire   +3 more sources

The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts [PDF]

, 2013
The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response.
A Fotovati, A Karaczyn, B Chen, B Xu, Baosheng Chen, CR Roh, D Pflueger, D Piquemal, DM Byers, DM Nelson, E Alsat, E Shaw, EA Mostaghel, Eric Y. Chuang, EU Jung, HJ Kliman, J Hwang, Jacob C. Larkin, JF Mouillet, JR Hickok, K Hirata, K Kokame, K Ogata, KJ Livak, KT Kim, L Aravind, L Kalaydjieva, LW Donaldson, M Hunter, M Hunter, MA Zoroddu, N van Belzen, NT Le, O Genbacev, P Lachat, RB Donker, RH King, RK Riemer, RP Caruso, S Bandyopadhyay, S Chen, S Sibold, S Smith, S Stein, SJ Choi, SK Kachhap, SK Kurdistani, T Fujii, T Matsugaki, T Mishima, T Okuda, T Sugiki, TM Lin, V Melotte, VM Banz, W Ulrix, WT Schaiff, X Qu, X Xu, Xiao-Hua Shi, Y Sadovsky, Y Sadovsky, Y Song, Y Taketomi, Y Zhou, Yoel Sadovsky, Z Chen, Z Kovacevic   +67 more
core   +7 more sources

Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells [PDF]

Clinics
OBJECTIVES: Hypoxia leads to endothelial cell inflammation, apoptosis, and damage, which plays an important role in the complications associated with ischemic cardiovascular disease.
Xiaohui Zhou, Jing Liu, Siyi Yang, Yanguang Su, Zhipeng Meng, Yuqin Hu   +5 more
doaj   +2 more sources

Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways [PDF]

, 2016
International audienceBackground: Several studies show that bone marrow (BM) microenvironment and hypoxia condition can promote the survival of leukemic cells and induce resistance to anti-leukemic drugs.
C. Heuclin, C. Petit, F. Gouel, I. Dubus, J. P. Vannier, K. Roget   +5 more
core   +4 more sources