Results 81 to 90 of about 599,693 (212)

Hypoxia-ischemia and retinal ganglion cell damage

Clinical Ophthalmology, 2008
Charanjit Kaur1, Wallace S Foulds2, Eng-Ang Ling11Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Singapore Eye Research Institute, SingaporeAbstract: Retinal hypoxia is the potentially blinding ...
Charanjit Kaur, Wallace S Foulds, Eng-Ang Ling   +2 more
doaj  

Hypoxia amplifies arecoline-induced invasion and metastasis in oral squamous cell carcinoma – Insights into TGF-β1 signaling and collagen production

Journal of Dental Sciences
Background/Purpose: Betel quid chewing is a major risk factor for oral squamous cell carcinoma (OSCC), largely due to arecoline, a key alkaloid. Hypoxia, common in the tumor microenvironment, also influences cancer progression.
Feng-Cheng Wu, Chun-Chan Ting, Jiiang-Huei Jeng, Hangshen Chen, Yong-Deok Kim, Chia-Chen Wu, Yu-Hsun Kao, Chih-Huang Tseng, Yuk-Kwan Chen, Toru Ogasawara, Kazuto Hoshi, Wen-liang Lo, Tetsu Takahashi, Yi-Hsin Yang, Edward Chengchuan Ko   +14 more
doaj   +1 more source

Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway

Cell Adhesion & Migration, 2020
A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors.
Joanna Pastwińska, Aurelia Walczak-Drzewiecka, Magdalena Łukasiak, Marcin Ratajewski, Jarosław Dastych   +4 more
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Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. [PDF]

, 2016
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge's disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment ...
Appenzeller, Otto, Azad, Priti, Bafna, Vineet, Cabrales, Pedro J, Haddad, Gabriel G, Hsiao, Yu Hsin, Poulsen, Orit, Ronen, Roy, Zhao, Huiwen W, Zhou, Dan   +9 more
core  

Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide [PDF]

, 2013
Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem.
Ali, Irshad, Audi, Said H., Densmore, John C., Husnain, Fouad, Jacobs, Elizabeth R., Konduri, G. Ganesh, Medhora, Meetha, Nanchal, Rahul   +7 more
core   +2 more sources

Identification of Hypoxia‐ALCAMhigh Macrophage‐ Exhausted T Cell Axis in Tumor Microenvironment Remodeling for Immunotherapy Resistance

Advanced Science
Although hypoxia is known to be associated with immune resistance, the adaptability to hypoxia by different cell populations in the tumor microenvironment and the underlying mechanisms remain elusive.
Zhenzhen Xun, Huanran Zhou, Mingyi Shen, Yao Liu, Chengcao Sun, Yanhua Du, Zhou Jiang, Liuqing Yang, Qing Zhang, Chunru Lin, Qingsong Hu, Youqiong Ye, Leng Han   +12 more
doaj   +1 more source

Tip60-HDAC8-SMURF2-mediated β-TrCP1 degradation is a key mechanism for hypoxia-induced cell death and tissue injury

Cellular and Molecular Life Sciences
The accumulation of HIFs regulated by the PHD-pVHL pathway represents the classical mechanism that transcriptionally mediates cellular adaptation to hypoxia. Extensive hypoxic stress activates cell death.
Sheng Li, Bo-Wen Zhang, Zi-Juan Wei, Yan Xi, Guo-An Zhang, Yue Zhang, De-Chi Kou, Xiao-Peng Song, Jing Huang, Ping Song, Ke-Yi Liang, Shuai-Shuai Pei, Hong-Yu Feng, Si-Ping Li, Qian-Qian Lou, Yue Liu, Kun-Hou Yao, Lu Yang, Su Chen   +18 more
doaj   +1 more source

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways [PDF]

, 2014
Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide adenine
Allison, Simon J., Granchi, C., Knight, J.R.P., Milner, J., Minutolo, F., Phillips, R.M., Rani, R.   +6 more
core   +1 more source

Cell-line dependent effects of hypoxia prior to irradiation in squamous cell carcinoma lines

Clinical and Translational Radiation Oncology, 2017
Purpose: To assess the impact of hypoxia exposure on cellular radiation sensitivity and survival of tumor cells with diverse intrinsic radiation sensitivity under normoxic conditions. Materials and methods: Three squamous cell carcinoma (SCC) cell lines,
Franziska Hauth, Mahmoud Toulany, Daniel Zips, Apostolos Menegakis   +3 more
doaj   +1 more source

Got Oxygen? Studies on Mesenchymal Cell Hypoxia Inducible Factor-1α in Lung Development. [PDF]

Am J Respir Cell Mol Biol, 2023
Stevens RP, Lee JY, Bauer N, Stevens T.
europepmc   +1 more source