Results 101 to 110 of about 3,688,571 (346)

Effect of interactions between granulosa and thecal cells on meiotic arrest in bovine oocytes [PDF]

, 1994
Fumikazu Kotsuji, M. Kubo, T. Tominaga
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1; referees: 4 approved]

F1000Research, 2017
Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essential in the case of solitary migrating cells (for example, immune cells), it becomes particularly important in collective cell migration, in which cells ...
Rocio Aguilar-Cuenca, Clara Llorente-Gonzalez, Carlos Vicente, Miguel Vicente-Manzanares   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Interplay between T3SS effectors, ExoY activation, and cGMP signaling in Pseudomonas aeruginosa infection

Nature Communications
The Type III Secretion System (T3SS) of Pseudomonas aeruginosa injects effector proteins into host cells to subvert cellular processes and promote infection. While the roles of several T3SS effectors in virulence are well established, the function of the
Vincent Deruelle, Gabrielle Dupuis, Dorothée Raoux-Barbot, Elysa Lim, Roberto Ponce-López, Magda Teixeira Nunes, Daniel Ladant, Louis Renault, Undine Mechold   +8 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Targeting the plasticity of intestinal neutrophils: bidirectional regulation strategies by natural products

Frontiers in Immunology
Historically, neutrophils have been regarded primarily as pro-inflammatory cells, yet recent advancements have revealed their phenotypic heterogeneity and functional plasticity with versatile immunophenotypes.
Ruotong Kang, Anqi Sun, Jiayin Yang, Linyuan Chang, Wenguang Sun, Fushun Kou, Yuan Cheng   +6 more
doaj   +1 more source

Host-Pathogen Interactions in the Plasmodium-Infected Mouse Liver at Spatial and Single-Cell Resolution

, 2023
Franziska Hildebrandt, Miren Urrutia Iturritza, C. Zwicker, Bavo Vanneste, Noémi Van Hul, Elisa Semle, Tales Vicari Pascini, Sami Saarenpää, Mengxiao He, Emma Andersson, Charlotte L. Scott, Joel Vega-Rodríguez, Joakim Lundeberg, Johan Ankarklev   +13 more
openalex   +1 more source