Results 251 to 260 of about 3,688,571 (346)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Mechanical Cell Interactions on Curved Interfaces. [PDF]

Bull Math Biol
Buenzli PR, Kuba S, Murphy RJ, Simpson MJ.   +3 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

An interleukin-27-centered cytokine circuit regulates macrophage and T cell interactions in autoimmune diabetes. [PDF]

iScience
Ciecko AE, Nabi R, Drewek A, Schauder DM, Zakharov PN, Wan X, Lieberman SM, Cui W, Hessner MJ, Lin CW, Chen YG.   +10 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Tumour cell-bone cell interactions in breast cancer bone metastases : mechanisms and effects of therapies

, 2012
Hannah K. Brown
openalex   +1 more source

Comparison of the metabolically active cells among the treatment group (L. sericata and L. major in RPMI 1640 medium supplemented with 10% serum), negative control group (L. sericata in RPMI 1640 medium with 10% serum), and positive control group (L. major in RPMI 1640 medium with 10% serum) outside the larval body, following a four-hour interaction.

Azam Malekian (22477905), Naseh Maleki-Ravasan (3626054), Somayeh Mohammadi (1751860), Ali Khamesipour (62371), Parviz Parvizi (6421373)   +4 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

A newly isolated giant virus, ushikuvirus, is closely related to clandestinovirus and shows a unique capsid surface structure and host cell interactions. [PDF]

J Virol
Bae J, Hatori N, Burton-Smith RN, Murata K, Takemura M.   +4 more
europepmc   +1 more source