Results 21 to 30 of about 3,688,571 (346)

Recent advances in understanding Listeria monocytogenes infection: the importance of subcellular and physiological context [version 1; referees: 3 approved]

F1000Research, 2017
The bacterial pathogen Listeria monocytogenes (Lm) is the causative agent of listeriosis, a rare but fatal foodborne disease. During infection, Lm can traverse several host barriers and enter the cytosol of a variety of cell types. Thus, consideration of
Daryl J. V. David, Pascale Cossart
doaj   +1 more source

Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters

Molecular Therapy: Nucleic Acids, 2021
The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have been no
Ryan P. Goguen, Olivier Del Corpo, Camille M.G. Malard, Aïcha Daher, Sergio P. Alpuche-Lazcano, Michelle J. Chen, Robert J. Scarborough, Anne Gatignol   +7 more
doaj   +1 more source

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. [PDF]

, 2017
T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Coles, Marc, Debes, Gudrun F., Detmar, Michael, Frei, Thomas, Halin, Cornelia, Hunter, Morgan C., Melero, Ignacio, Proulx, Steven T, Rouzaut, Ana, Russo, Erica, Teijeira, Alvaro   +10 more
core   +3 more sources

Symbiotic Cell Differentiation and Cooperative Growth in Multicellular Aggregates

, 2016
As cells grow and divide under a given environment, they become crowded and resources are limited, as seen in bacterial biofilms and multicellular aggregates.
Kaneko, Kunihiko, Saito, Nen, Yamagishi, Jumpei F   +2 more
core   +5 more sources

An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy

Frontiers in Cellular and Infection Microbiology, 2019
Visceral leishmaniasis (VL), caused by digenetic protozoa of the genus Leishmania, is the most severe form of leishmaniasis. Leishmania infantum is one of the species responsible for VL and the disease caused is considered a zoonosis whose main reservoir
Ana Alice Maia Gonçalves, Jaqueline Costa Leite, Lucilene Aparecida Resende, Reysla Maria da Silveira Mariano, Patricia Silveira, Otoni Alves de Oliveira Melo-Júnior, Helen Silva Ribeiro, Diana Souza de Oliveira, Diogo Fonseca Soares, Thaiza Aline Pereira Santos, Alexandre Ferreira Marques, Alexsandro Sobreira Galdino, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Denise da Silveira-Lemos, Rodolfo Cordeiro Giunchetti   +15 more
doaj   +1 more source

A rewiring model of intratumoral interaction networks. [PDF]

, 2019
Intratumoral heterogeneity (ITH) has been regarded as a key cause of the failure and resistance of cancer therapy, but how it behaves and functions remains unclear.
Alizadeh, Badano, Bedard, Castro-Giner, Cleary, Couzin-Frankel, Easton, Enriquez-Navas, Fachal, Garcia-Closas, Gillies, Gosik, Greaves, Jørgensen, Kallioniemi, Komarova, Korolev, Lesseur, Li, Ling, McGranahan, Merlo, Nowak, Qazi, Saadatpour, Smith, Stadler, Tabassum, Vittecoq, Vogelstein, von Loga, von Neumann, Waclaw, Watson, Welch, Zhu   +35 more
core   +2 more sources

Dynamics of Natural Killer Cells Cytotoxicity in Microwell Arrays with Connecting Channels

Frontiers in Immunology, 2017
Natural killer (NK) cells serve an important role in immune system by recognizing and killing the potentially malignant cells without antigen sensitization, and could be promising in cancer therapy.
Yuanhao Xu, Yuanhao Xu, Shufan Zhou, Shufan Zhou, Yun Wah Lam, Yun Wah Lam, Stella W. Pang, Stella W. Pang   +7 more
doaj   +1 more source

Candida gut commensalism and inflammatory disease

Medicine in Microecology, 2020
The mammalian intestine harbors a collection of microbes ranging from viruses, archaea, protozoa, helminths, bacteria to fungi. This trans-kingdom community, the microbiota, has been demonstrated to modulate host immunity in health and disease.
Zi-Qi Gu, Kuo-Yao Tseng, Yu-Huan Tsai
doaj   +1 more source

A Review of Major Patents on Potential Malaria Vaccine Targets

Pathogens, 2023
Malaria is a parasitic infection that is a great public health concern and is responsible for high mortality rates worldwide. Different strategies have been employed to improve disease control, demonstrating the ineffectiveness of controlling vectors ...
Reysla Maria da Silveira Mariano, Ana Alice Maia Gonçalves, Diana Souza de Oliveira, Helen Silva Ribeiro, Diogo Fonseca Soares Pereira, Ingrid Soares Santos, Daniel Ferreira Lair, Augusto Ventura da Silva, Alexsandro Sobreira Galdino, Miguel Angel Chávez-Fumagalli, Denise da Silveira-Lemos, Walderez Ornelas Dutra, Rodolfo Cordeiro Giunchetti   +12 more
doaj   +1 more source

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix [PDF]

, 2015
Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and diseased tissues--particularly in development, wound healing, tissue regeneration and cancer--the mechanisms that direct the assembly and regulate hierarchical ...
Gourdon, Delphine, Klotzsch, Enrico, Kubow, Kristopher E., Luna, Sheila, Smith, Michael L., Vogel, Viola, Vukmirovic, Radmila, Zhe, Lin   +7 more
core   +2 more sources