Results 61 to 70 of about 3,688,571 (346)

Polymeric Delivery Systems as a Potential Vaccine against Visceral Leishmaniasis: Formulation Development and Immunogenicity

Vaccines, 2023
Recent studies suggest that the association of antigens in microparticles increases the anti-Leishmania vaccine immunogenicity. This study aims to investigate the in situ effect of the adjuvant performance consisting of chitosan-coated poly(D,L-lactic ...
João Guilherme Lino da Silva, Ana Alice Maia Gonçalves, Liliam Teixeira Oliveira, Giani Martins Garcia, Maurício Azevedo Batista, Ludmila Zanandreis de Mendonça, Kelvinson Fernandes Viana, Rita de Cássia Oliveira Sant’Ana, Otoni Alves de Oliveira Melo Júnior, Denise Silveira-Lemos, Walderez Ornelas Dutra, Olindo Assis Martins-Filho, Alexsandro Sobreira Galdino, Sandra Aparecida Lima de Moura, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti   +15 more
doaj   +1 more source

The Role of Intracellular Interactions in the Collective Polarization of Tissues and its Interplay with Cellular Geometry

, 2019
Planar cell polarity (PCP), the coherent in-plane polarization of a tissue on multicellular length scales, provides directional information that guides a multitude of developmental processes at cellular and tissue levels.
Mani, Madhav, Shadkhoo, Shahriar
core   +1 more source

A structural systematic study of four isomers of difluoro-N-(3-pyridyl)benzamide [PDF]

, 2009
The four isomers 2,4-, (I), 2,5-, (II), 3,4-, (III), and 3,5-difluoro-N-(3-pyridyl)benzamide, (IV), all with formula C12H8F2N2O, display molecular similarity, with interplanar angles between the C6/C5N rings ranging from 2.94 (11)° in (IV) to 4.48 (18 ...
Anderson, Frankie P., Gallagher, John F., Lough, Alan J., McMahon, Joyce   +3 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Core–Shell Chitosan Particles Targeting Membrane-Bound Heat Shock Protein 70 for Cancer Therapy

Nanomaterials
Anti-cancer targeted therapy is a promising approach. However, the identification of target molecules over-expressed in a wide range of tumors remains a significant challenge.
Elena V. Svirshchevskaya, Valentina V. Kostenko, Anna A. Boyko, Maxim Shevtsov, Roman V. Kholodenko, Maria V. Grechikhina, Iuliia A. Gracheva, Alexey Yu. Fedorov, Alexander M. Sapozhnikov   +8 more
doaj   +1 more source

Surface modification of hydrophobic polymers for improvement of endothelial cell-surface interactions [PDF]

, 1992
The aim of this study is to improve the interaction of endothelial cells with polymers used in vascular prostheses. Polytetrafluoroethylene (PTFE; Teflon) films were treated by means of nitrogen and oxygen plasmas.
A Dekker, AD Callow, C Willems, D Klee, G Plate, JA Chinn, JD Andrade, K Berger, KJ Pratt, MB Herring, PB Wachem Van, PB Wachem Van, PB Wachem Van, PB Wachem Van, RA Wagenen Van, RA Wagenen Van, WH Pearce   +16 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Models for pattern formation in somitogenesis: a marriage of cellular and molecular biology [PDF]

, 2002
Somitogenesis, the process by which a bilaterally symmetric pattern of cell aggregations is laid down in a cranio-caudal sequence in early vertebrate development, provides an excellent model study for the coupling of interactions at the molecular and ...
Gavaghan, D. J., Houston, P., Maini, P. K., McInerney, D., Schnell, S.   +4 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Myo-REG: A Portal for Signaling Interactions in Muscle Regeneration

Frontiers in Physiology, 2019
Muscle regeneration is a complex process governed by the interplay between several muscle-resident mononuclear cell populations. Following acute or chronic damage these cell populations are activated, communicate via cell–cell interactions and/or ...
Alessandro Palma, Andrea Cerquone Perpetuini, Federica Ferrentino, Claudia Fuoco, Cesare Gargioli, Giulio Giuliani, Marta Iannuccelli, Luana Licata, Elisa Micarelli, Serena Paoluzi, Livia Perfetto, Lucia Lisa Petrilli, Alessio Reggio, Marco Rosina, Francesca Sacco, Simone Vumbaca, Alessandro Zuccotti, Luisa Castagnoli, Gianni Cesareni, Gianni Cesareni   +19 more
doaj   +1 more source