Results 71 to 80 of about 3,688,571 (346)

Inferring the Sign of Kinase-Substrate Interactions by Combining Quantitative Phosphoproteomics with a Literature-Based Mammalian Kinome Network

, 2010
Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of ...
Hernandez, Marylens, Lachmann, Alexander, Ma'ayan, Avi, Xiao, Kunhong, Zhao, Shan   +4 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Poisson-Boltzmann Theory of Charged Colloids: Limits of the Cell Model for Salty Suspensions

, 2010
Thermodynamic properties of charge-stabilised colloidal suspensions are commonly modeled by implementing the mean-field Poisson-Boltzmann (PB) theory within a cell model.
A R Denton, Belloni L, Brukhno A, Denton A R, Denton A R, Denton A R, Derjaguin B V, Deserno M, Diehl A, Dobnikar J, Evans D F, Hansen J-P, Israelachvili J, Levin Y, Levin Y, Linse P, Lu B, Löwen H, Oosawa F, van Roij R, Verwey E J W, von Grünberg H H, Warren P B   +22 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Iron Oxide Colloidal Nanoclusters as Theranostic Vehicles and Their Interactions at the Cellular Level

Nanomaterials, 2018
Advances in surfactant-assisted chemical approaches have led the way for the exploitation of nanoscale inorganic particles in medical diagnosis and treatment. In this field, magnetically-driven multimodal nanotools that perform both detection and therapy,
Athanasia Kostopoulou, Konstantinos Brintakis, Eirini Fragogeorgi, Amalia Anthousi, Liberato Manna, Sylvie Begin-Colin, Claire Billotey, Anthi Ranella, George Loudos, Irene Athanassakis, Alexandros Lappas   +10 more
doaj   +1 more source

Laser-plasma interactions with a Fourier-Bessel Particle-in-Cell method

, 2015
A new spectral particle-in-cell (PIC) method for plasma modeling is presented and discussed. In the proposed scheme, the Fourier-Bessel transform is used to translate the Maxwell equations to the quasi-cylindrical spectral domain.
Agustin Lifschitz, Birdsall C. K., Boris J. P., Gorbunov L. M., Haber I., Igor A. Andriyash, Remi Lehe, Taflove A.   +7 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

THE ROLE OF INTERACTIONS BETWEEN TROPHOBLASTDERIVED EXTRACELLULAR MICROVESICLES, IMMUNE CELLS AND ENDOTHELIUM IN PATHOGENESIS OF PRE-ECLAMPSIA

Медицинская иммунология, 2018
Pre-eclampsia is a multisystemic disease that occurs in the second half of pregnancy, being characterized by the development of hypertension and proteinuria.
G. O. Kerksehko, A. V. Korenevsky, D. I. Sokolov, S. A. Selkov   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source