Results 141 to 150 of about 1,625,980 (311)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Multiwalled Carbon Nanotubes Interact with Macrophages and Influence Tumor Progression and Metastasis

Theranostics, 2012
Macrophages are one of the most important types of immune effector cells and are closely associated with tumor progression and metastasis. In this work, we investigated the influences of oxidized multiwalled carbon nanotubes (o-MWCNT) on macrophages that
Man Yang, Jie Meng, Xuelian Cheng, Jing Lei, Hua Guo, Weiqi Zhang, Hua Kong, Haiyan Xu
doaj  

Establishment of human induced pluripotent stem cell line MURAi001-A from skin fibroblasts of a patient carrying a c.4404A > G mutation in the TET1 gene

Stem Cell Research
Ten-Eleven Translocation methylcytosine dioxygenase 1 (TET1) is known to play a broad tumor suppressor role through demethylating and activating tumor suppressor genes. TET1 missense mutations are previously reported in many types of leukemia.
Amornrat Tangprasittipap, Pawarit Innachai, Sukanya Chumchuen, Wararat Chiangjong, Natini Jinawath, Nongnuch Sirachainan, Suradej Hongeng   +6 more
doaj   +1 more source

The Effect of Sodium Valproate on the Glioblastoma U87 Cell Line Tumor Development on the Chicken Embryo Chorioallantoic Membrane and on EZH2 and p53 Expression. [PDF]

Biomed Res Int, 2017
Kavaliauskaitė D, Stakišaitis D, Martinkutė J, Šlekienė L, Kazlauskas A, Balnytė I, Lesauskaitė V, Lesauskaitė V, Valančiūtė A.   +8 more
europepmc   +1 more source

Cytotoxicity Study Of Mezzetiaparviflorabecc. Woodbark [PDF]

, 2013
The cytotoxic activity of acetone insoluble extract of MezzetiaparvifloraBecc. Wood bark was evaluated on HeLa cell line and it was compared with normal vero cell line to confirming the use of the plant as a traditional medicine for tumor.
Lawrence, G. S. (Gatot), Manggau, M. A. (Mirianti), Mufidah, M. (Mufidah), Wahyudin, E. (Elly), Wahyuningsih, M. S. (M)   +4 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line. [PDF]

, 1982
This study demonstrates that an uncharacterized soluble factor produced in concanavalin A-induced rat spleen cell suspensions has the capacity to induce the increased expression of cell surface H-2K and H-2D molecules and the expression of I-region gene ...
Lanier, LL, Walker, EB, Warner, NL
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Adoptive immunotherapy monitored by micro-MRI in experimental colorectal liver metastasis [PDF]

, 2002
In this study we used the colon carcinoma DHDK12 cell line and generated single metastasis after subcapsular injection in BDIX rats as an experimental tumor model.
A. Gervais, D. Lechaux, F. Franconi, L. Dazord, L. Lemaire, N. Rioux-Leclercq, P.A. Eliat, V. Catros-Quemener   +7 more
core   +1 more source