Results 31 to 40 of about 3,159,930 (315)

Fibroblasts cell lines misclassified as cancer cell lines [PDF]

, 2017
Large collections of immortalized cancer cell lines have been widely used as model systems for cancer research and drug discovery. Some of these models however display more fibroblast-like than cancer-like characteristics based on their genetic and genomic characterization. The correct annotation of these cell lines remains a challenge. Here, we report
de Weck, Antoine, Bitter, Hans, Kauffmann, Audrey   +2 more
openaire   +1 more source

Gynaecological cancers and their cell lines [PDF]

Journal of Cellular and Molecular Medicine, 2021
AbstractCell lines are widely used for various research purposes including cancer and drug research. Recently, there have been studies that pointed to discrepancies in the literature and usage of cell lines. That is why we have prepared a comprehensive overview of the most common gynaecological cancer cell lines, their literature, a list of currently ...
Kristijan Skok, Lidija Gradišnik, Uroš Maver, Nejc Kozar, Monika Sobočan, Iztok Takač, Darja Arko, Rajko Kavalar   +7 more
openaire   +2 more sources

Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells [PDF]

, 2009
© 2009 by The American Society for Cell Biology.The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component
Modino, S, Cooley, C, Cooley, C., Farr, CJ, Farr, C. J., Slijepcevic, P., Baird, K. M., Stewart, J. L., Slijepcevic, P, Baird, KM, Wenner, T., Stewart, JL, Faure, V., Morrison, C. G., Morrison, CG, Wenner, T, Modino, S., Faure, V   +17 more
core   +1 more source

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas [PDF]

, 2021
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the β ...
Rackham, Chloe, Lambert, C, Evans, Ian, Sancho, Rocio; id_orcid, Messal, Hendrik A., Jones, P, Hubber, Ella-louise, Messal, HA, Lambert, Christopher, Behrens, Axel, Heimberg, Harry, Hubber, E-L, Heimberg, H, Rackham, C, Jones, Peter; id_orcid, Evans, I, Gribben, C, Behrens, A, Gribben, Christopher, Sancho, R   +19 more
core   +1 more source

Establishment and Characterization of Feline Mammary Tumor Patient-Derived Xenograft Model

Animals, 2021
Feline mammary tumor is a relatively commonly diagnosed neoplasm in the cat. Development of new veterinary cancer therapies is limited by the shortage of in vivo models that reproduce tumor microenvironment and metastatic progression. Four feline mammary
Hsiao-Li Chuang, Yi-Chih Chang, Yi-Ting Huang, Jiunn-Wang Liao, Pei-Ling Kao, Yi-Fei Chen, Bin-Yin Lin, Yi-Lo Lin, Ter-Hsin Chen, Yu-Chih Wang   +9 more
doaj   +1 more source

Role of p52 (NF-κB2) in LPS tolerance in a human B cell line [PDF]

, 1999
Cells of the weakly CD14 positive human B cell line RPMI 8226, clone 1, will mobilize NF-κB (p50/p65 and p50/p50) proteins and produce TNF mRNA when stimulated with lipopolysaccharide (LPS), When such cells are precultured with a low amount of LPS (50 ...
Wedel, Angela, Sulski, Gabi, Kuprash, Dmitry, H.W. Loems Ziegler-Heitbrock, Angela Wedel, Marion Frankenberger, Irmhild Petersmann, Nedospasov, Sergei, Frankenberger, Marion, Petersmann, Irmhild, Ziegler-Heitbrock, H. W. Loems, Dmitry Kuprash, Sergei Nedospasov, Gabi Sulski   +13 more
core   +1 more source

Transplants of Encapsulated Rat Choroid Plexus Cells Exert Neuroprotection in a Rodent Model of Huntington's Disease

Cell Transplantation, 2007
Choroid plexus (CP) epithelial cells secrete several neurotrophic factors and have been used in transplantation studies designed to impart neuroprotection against central nervous system (CNS) trauma. In the present study, CP was isolated from adult rats,
Cesario V. Borlongan, Christopher G. Thanos, Steven J. M. Skinner, Marilyn Geaney, Dwaine F. Emerich   +4 more
doaj   +1 more source

Generation of an iPSC line from a retinitis pigmentosa patient carrying a homozygous mutation in CERKL and a healthy sibling

Stem Cell Research, 2019
Dermal fibroblasts from an autosomal recessive retinitis pigmentosa (RP) patient, homozygous for the mutation c.769 C>T, p.Arg257Ter, in CERKL (Ceramide Kinase-Like) gene, and a healthy sibling were derived and reprogrammed by Sendai virus. The generated
Arantxa Bolinches-Amorós, Marian León, Verónica del Buey Furió, Gemma Marfany, Roser Gonzàlez-Duarte, Slaven Erceg, Dunja Lukovic   +6 more
doaj   +1 more source

Establishment of A Novel Paclitaxel-Resistant Triple-Negative Breast Cancer Cell Line

Journal of Health Science and Medical Research (JHSMR), 2023
Objective: Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, and is associated with poor prognosis. Paclitaxel, a microtubule-binding agent, and chemotherapeutic agent, has been widely used in the management of
Thanaporn Khunpitak, Pasarat Khongkow
doaj   +1 more source

Downregulation of Tumor Necrosis Factor Expression in the Human Mono-Mac-6 Cell Line [PDF]

, 1989
Mono-Mac-6 cells, but not U937 cells, can be Induced to rapidly express tumor necrosis factor (TNF) mRNA and protein when triggered with Ilpopolysaccharlde (LPS) at 1 pg/mI. Preincubatlon of the cells for 3 d with low amounts of LPS (10 ng/mI) results In
Thiel, Corinna, Haas, Jürgen G., Ziegler-Heitbrock, H. W. Löms, Blömer, Kathi, Weiss, Elisabeth H., Riethmüller, Gert   +5 more
core   +1 more source