Results 71 to 80 of about 15,661,277 (406)

Membrane repair against H. pylori promotes cancer cell proliferation [PDF]

, 2010
Membrane repair is a universal response against physical and biological insults and enables cell survival. Helicobacter pylori is one of the most common human pathogens and the first formally recognized bacterial carcinogen associated with gastric cancer.
Chiung-Nien Chen, Hsuan-Cheng Huang, Hsueh-Fen Juan, Jin-Town Wang, Li-Ling Lin, Satoshi Ogihara   +5 more
core   +1 more source

Volume changes during active shape fluctuations in cells [PDF]

, 2015
Cells modify their volume in response to changes in osmotic pressure but it is usually assumed that other active shape variations do not involve significant volume fluctuations.
Kardash, Elena, La Porta, Caterina A. M., Salman, Oguz Umut, Taloni, Alessandro, Truskinovsky, Lev, Zapperi, Stefano   +5 more
core   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

Nature Communications, 2018
Multidrug transporters possess several drug binding sites. Here the authors describe a transport path specific for planar aromatic cations in the E. coli multi-drug transporter AcrB.
Martijn Zwama, Seiji Yamasaki, Ryosuke Nakashima, Keisuke Sakurai, Kunihiko Nishino, Akihito Yamaguchi   +5 more
doaj   +1 more source

X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB

Communications Biology, 2021
Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside.
Lan Guan, Parameswaran Hariharan
doaj   +1 more source

TTL-Expression Modulates Epithelial Morphogenesis

Frontiers in Cell and Developmental Biology, 2021
Epithelial monolayer formation depends on the architecture and composition of the microtubule cytoskeleton. Microtubules control bidirectional trafficking and determine the positioning of structural cellular proteins.
Manuel Müller, Manuel Müller, Karina Ringer, Karina Ringer, Florian Hub, Natalia Kamm, Thomas Worzfeld, Thomas Worzfeld, Thomas Worzfeld, Ralf Jacob, Ralf Jacob   +10 more
doaj   +1 more source

Creation and Reproduction of Model Cells with Semipermeable Membrane

, 2008
A high activity of reactions can be confined in a model cell with a semipermeable membrane in the Schl\"ogl model. It is interpreted as a model of primitive metabolism in a cell.
Dyson F. J., Elowitz M. B., Kondo S., Langton C. G., Murray J. D., Nicolis G., Noireaux V., Oparin A. I., Paulsson J., Sakaguchi H., Schlögl F., Togashi Y., Vanag V. K., Winston D.   +13 more
core   +1 more source

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
A Degterev, A Müller, A Müller, AE Deghmane, Anke Harsman, B Shanmugavadivu, Dirk Günther, DM Walther, DR Voelker, E Gottlieb, E Gottlieb, Elke A. Dian-Lothrop, Eva Hauf, FJ Bauer, FJ Castora, G Kroemer, G Schatz, Hank Steven Seifert, I Guilvout, IE Gentle, Ines Herrmann, J Song, JE Chipuk, JF Weel, Joachim Rassow, K Hill, Katharina Ross, Krishnaraj Rajalingam, L Scorrano, LA Pon, LC Armstrong, LM Loew, M Meinecke, MC Wei, Michael Meinecke, MP Bos, N Bolender, N Pfanner, N Wiedemann, N Wiedemann, O Kepp, O Kepp, Oliver Kepp, P Massari, P Massari, P Mueller, R Voulhoux, RD Taylor, Richard Wagner, Robert Hurwitz, RP Zahedi, S Desagher, S Kutik, S Makino, SA Paschen, SA Paschen, T Krimmer, T Rudel, Thomas Rudel, V Kozjak, V Kozjak-Pavlovic, V Robert, Vera Kozjak-Pavlovic, Volker Brinkmann, W Neupert   +64 more
core   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation

Nature Communications, 2016
It is unclear how the cytoskeleton acts to assist in TGF-β signalling downstream of the receptor. Here, in zebrafish, the authors show that the actin-bundling protein FSCN1 interacts with TGF-β type I receptors ALK 4 and 5, enabling actin filament ...
Zhaoting Liu, Guozhu Ning, Ranran Xu, Yu Cao, Anming Meng, Qiang Wang   +5 more
doaj   +1 more source