Results 111 to 120 of about 1,482,013 (279)

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

Frontiers in Immunology, 2018
Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles.
Zhengzhao Liu, Zhengzhao Liu, Zhengzhao Liu, Zhengzhao Liu, Hongming Li, Hongming Li, Chungu Hong, Menglu Chen, Menglu Chen, Tao Yue, Tao Yue, Chunyuan Chen, Zhenxing Wang, Qing You, Qing You, Chuanyin Li, Chuanyin Li, Qinjie Weng, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Ronggui Hu, Ronggui Hu   +24 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

RNA transport during TMV cell-to-cell movement

Frontiers in Plant Science, 2012
Studies during the last twenty-five years have provided increasing evidence for the ability of plants to support the cell-to-cell and systemic transport of RNA molecules and that this process plays a role in plant development and in the systemic ...
Eduardo José ePeña, Manfred eHeinlein, Manfred eHeinlein   +2 more
doaj   +1 more source

Dand5 is involved in zebrafish tailbud cell movement. [PDF]

Front Cell Dev Biol, 2022
Bota C, Martins GG, Lopes SS.
europepmc   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Force-Control for the Automated Footwear Testing System [PDF]

, 2005
The Automated Footwear Testing System (AFTS) is a robotic system designed to replicated the movement and loading of a shoe as it contacts the ground during common human movements.
Lewis, Greg
core  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

Scientific Reports, 2019
Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA.
Marijke Grau, Max Jerke, Elie Nader, Alexander Schenk, Celine Renoux, Bianca Collins, Thomas Dietz, Daniel Alexander Bizjak, Philippe Joly, Wilhelm Bloch, Philippe Connes, Aram Prokop   +11 more
doaj   +1 more source

Collagens in avian neural crest development: distribution in vivo and migration-promoting ability in vitro [PDF]

, 1991
This study examines the spatiotemporal distribution of collagen (Col) types I-V and IX during neural crest development in vivo and their ability to support neural crest cell movement in vitro.
Bronner-Fraser, Marianne, Krotoski, Danuta, Perris, Roberto   +2 more
core  

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source