Results 111 to 120 of about 1,618,106 (339)

Energy substrate supplementation increases ATP levels and is protective to PD neurons

Current Research in Pharmacology and Drug Discovery
Alteration of mitochondrial metabolism by various mutations or toxins leads to various neurological conditions. Age-related changes in energy metabolism could also play the role of a trigger for neurodegenerative disorders.
Andrey Y. Vinokurov, Marina Y. Pogonyalova, Larisa Andreeva, Andrey Y. Abramov, Plamena R. Angelova   +4 more
doaj   +1 more source

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

Frontiers in Immunology, 2018
Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles.
Zhengzhao Liu, Zhengzhao Liu, Zhengzhao Liu, Zhengzhao Liu, Hongming Li, Hongming Li, Chungu Hong, Menglu Chen, Menglu Chen, Tao Yue, Tao Yue, Chunyuan Chen, Zhenxing Wang, Qing You, Qing You, Chuanyin Li, Chuanyin Li, Qinjie Weng, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Ronggui Hu, Ronggui Hu   +24 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Towards a digital model of zebrafish embryogenesis. Integration of Cell Tracking and Gene Expression Quantification [PDF]

, 2010
We elaborate on a general framework composed of a set of computational tools to accurately quantificate cellular position and gene expression levels throughout early zebrafish embryogenesis captured over a time-lapse series of in vivo 3D images.
Bourgine, Paul, Castro González, Carlos, Desnoulez, Sophie, Douloquin, Louise, Ledesma Carbayo, María Jesús, Luengo Oroz, Miguel Ángel, Melani, Camilo, Peyrieras, Nadine, Santos Lleo, Andres de, Savy, Thierry   +9 more
core   +1 more source

A mechanism of regucalcin knock-down in the promotion of proliferation and movement of human cervical cancer HeLa cells [PDF]

, 2019
Xiao‐Long Li, Ying-Wen Huang, Pengfei Wang, Wei Song, Qingmei Yao, Qiping Hu, Sufang Zhou   +6 more
openalex   +1 more source

Functional architecture of M1 cells encoding movement direction [PDF]

, 2022
Caterina Mazzetti, Alessandro Sarti, Giovanna Citti   +2 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Quantum dots modulate intracellular Ca2+ level in lung epithelial cells

International Journal of Nanomedicine, 2017
Huijuan Yin,1 Jacopo M Fontana,1 Johan Solandt,1,2 Johnny Israelsson Jussi,1 Hao Xu,1 Hjalmar Brismar,1 Ying Fu1 1Section of Cellular Biophysics, Department of Applied Physics, Royal Institute of Technology (KTH), Science for Life Laboratory, Solna ...
Yin HJ, Fontana JM, Solandt J, Jussi JI, Xu H, Brismar H, Fu Y   +6 more
doaj  

Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

Scientific Reports, 2019
Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA.
Marijke Grau, Max Jerke, Elie Nader, Alexander Schenk, Celine Renoux, Bianca Collins, Thomas Dietz, Daniel Alexander Bizjak, Philippe Joly, Wilhelm Bloch, Philippe Connes, Aram Prokop   +11 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source