Results 91 to 100 of about 1,616,474 (251)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

New Advances in Understanding the Molecular Biology of Plant/Potyvirus Interactions

Molecular Plant-Microbe Interactions, 1999
In recent years, researchers have adopted many new technologies to help understand potyvirus pathogenesis. Their findings have illuminated key aspects of the interactions between the host and the virus, and between the virus and its aphid vector.
Frédéric Revers, Olivier Le Gall, Thierry Candresse, Andrew J. Maule   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Energy substrate supplementation increases ATP levels and is protective to PD neurons

Current Research in Pharmacology and Drug Discovery
Alteration of mitochondrial metabolism by various mutations or toxins leads to various neurological conditions. Age-related changes in energy metabolism could also play the role of a trigger for neurodegenerative disorders.
Andrey Y. Vinokurov, Marina Y. Pogonyalova, Larisa Andreeva, Andrey Y. Abramov, Plamena R. Angelova   +4 more
doaj   +1 more source

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

Frontiers in Immunology, 2018
Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles.
Zhengzhao Liu, Zhengzhao Liu, Zhengzhao Liu, Zhengzhao Liu, Hongming Li, Hongming Li, Chungu Hong, Menglu Chen, Menglu Chen, Tao Yue, Tao Yue, Chunyuan Chen, Zhenxing Wang, Qing You, Qing You, Chuanyin Li, Chuanyin Li, Qinjie Weng, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Ronggui Hu, Ronggui Hu   +24 more
doaj   +1 more source

Oxygen recombination in individual pressure vessel nickel-hydrogen batteries [PDF]

, 1986
A metal-hydrogen cell is described which avoids damage and retards flooding of the hydrogen electrodes by providing for chemical recombination of oxygen and hydrogen in areas or sites remote from the hydrogen electrodes.
Smithrick, J. J.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Translation and validation of the Pediatric Daytime Sleepiness Scale (PDSS) into Brazilian Portuguese

Jornal de Pediatria, 2016
Objective: The aim of this study was to translate and validate the Pediatric Daytime Sleepiness Scale (PDSS) into Brazilian Portuguese. Methods: The translation/validation process was carried out through translation, back translation, technical review ...
Érico P.G. Felden, Joana D. Carniel, Rubian D. Andrade, Andreia Pelegrini, Tâmile S. Anacleto, Fernando M. Louzada   +5 more
doaj   +1 more source