Results 101 to 110 of about 669,615 (306)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Cell Polarity and Morphogenesis: Functions and Mechanisms of Cell Divisions in Vertebrate Gastrulation [PDF]

, 2004
Gastrulation shapes a vertebrate embryo from an egg-shaped aggregate of cells. In many vertebrates, massive cell divisions occur during gastrulation. In this thesis, I investigate the pattern, function, and regulation of mitotic divisions in zebrafish ...
Gong, Ying, Ying Gong
core   +1 more source

A Pilot Study of Botulinum Toxin for Jerky, Position-Specific, Upper Limb Action Tremor

Tremor and Other Hyperkinetic Movements, 2016
Background: We aimed to investigate the efficacy and safety of botulinum toxin (BT) injections for jerky action tremor of the upper limb.Methods: We performed an uncontrolled, prospective study of electromyography (EMG)-guided BT injections for jerky ...
Tabish A. Saifee, Tiago Teodoro, Roberto Erro, Mark J. Edwards, Carla Cordivari   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Blaschko's lines, a pattern expressed in some dermatological illnesses

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
With the current advances of genetics several skin conditions with a lineal disposition due to cutaneous mosaicisms have been able to be diagnosed. Although there are five different patterns, Blaschko's lines are the most frequent ones.
Yordania Velázquez-Ávila, Maritza Morales-Solís, Julio Enrique Torres-Reyes   +2 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]

, 2007
Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Jones, Jon, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A.Blaheta, Stefan Berkhoff, Tobias Engl, Wedel, Steffen Alexander, Jonas, Dietger, Berkhoff, Stefan, Jon Jones, Borna Relja, Relja, Borna, Eva Weich, Steffen Wedel, Engl, Tobias A.   +15 more
core   +1 more source

Low, but Not High, Pulsating Fluid Shear Stress Affects Matrix Extracellular Phosphoglycoprotein Expression, Mainly via Integrin β Subunits in Pre-Osteoblasts

Current Issues in Molecular Biology
Matrix extracellular phosphoglycoprotein (Mepe), present in bone and dentin, plays important multifunctional roles in cell signaling, bone mineralization, and phosphate homeostasis.
Jianfeng Jin, Behrouz Zandieh-Doulabi
doaj   +1 more source

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

eLife, 2019
While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to replace the lost myocardium.
Hessel Honkoop, Dennis EM de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong D Nguyen, Cecilia de Heus, Laurence Garric, Mauro J Muraro, Adam Shoffner, Federico Tessadori, Joshua Craiger Peterson, Wendy Noort, Alberto Bertozzi, Gilbert Weidinger, George Posthuma, Dominic Grün, Willem J van der Laarse, Judith Klumperman, Richard T Jaspers, Kenneth D Poss, Alexander van Oudenaarden, Eldad Tzahor, Jeroen Bakkers   +23 more
doaj   +1 more source