Results 111 to 120 of about 669,615 (306)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Compatibility of the movement protein and the coat protein of cucumoviruses is required for cell-to-cell movement

Journal of General Virology, 2004
For the cell-to-cell movement of cucumoviruses both the movement protein (MP) and the coat protein (CP) are required. These are not reversibly exchangeable betweenCucumber mosaic virus(CMV) andTomato aspermy virus(TAV). The MP of CMV is able to function with the TAV CP (chimera RT), but TAV MP is unable to promote the cell-to-cell movement in the ...
Katalin, Salánki, Ákos, Gellért, Emese, Huppert, Gábor, Náray-Szabó, Ervin, Balázs   +4 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Systemic movement of FT mRNA and a possible role in floral induction [PDF]

, 2012
FLOWERING LOCUS T (FT) protein is known to be part of the mobile flowering inducing “florigen” signal in plants, but it may not be acting alone. This article reviews the data that FT mRNA can also move systemically throughout the plant and into the shoot
Hong, Yiguo, Yiguo eHong, Yiguo Hong, Stephen eJackson, Stephen D. Jackson, Jackson, Stephen D.   +5 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Temporal modulation of luminance adapts time constant of fly movement detectors [PDF]

, 1987
Borst A, Egelhaaf M. Temporal modulation of luminance adapts time constant of fly movement detectors. Biological Cybernetics. 1987;56(4):209-215.The time constant of movement detectors in the fly visual system has been proposed to adapt in response to ...
Egelhaaf, M., Borst, Alexander, Egelhaaf, Martin ; https://orcid.org/, Borst, A.   +3 more
core   +2 more sources

New Advances in Understanding the Molecular Biology of Plant/Potyvirus Interactions

Molecular Plant-Microbe Interactions, 1999
In recent years, researchers have adopted many new technologies to help understand potyvirus pathogenesis. Their findings have illuminated key aspects of the interactions between the host and the virus, and between the virus and its aphid vector.
Frédéric Revers, Olivier Le Gall, Thierry Candresse, Andrew J. Maule   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The JAK/STAT Pathway in Model Organisms Emerging Roles in Cell Movement [PDF]

, 2002
The JAK/STAT pathway was originally identified in mammals. Studies of this pathway in the mouse have revealed that JAK/STAT signaling plays a central role during hematopoeisis and other developmental processes.
Hou, Steven X., Steven X. Hou, Zhiyu Zheng, Xiu Chen, Norbert Perrimon, Zheng, Zhiyu, Chen, Xiu, Perrimon, Norbert   +7 more
core   +1 more source

Targeted therapy on glioma migration and invasion

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Malignant glioma, one of the most lethal malignancies, is the most common primary central nervous system tumor with a dismal prognosis. The major obstacle to cure and recurrence is diffuse invasion, which enables glioma cells to escape complete surgical ...
Tao LI, Long HAI, Xue⁃jun YANG
doaj