Results 121 to 130 of about 1,482,013 (279)

1D micro-nanopatterned integrin ligand surfaces for directed cell movement. [PDF]

Front Cell Dev Biol, 2022
Levario-Diaz V, Alvarado RE, Rodriguez-Quinteros CM, Fink A, Christian J, Feng W, Cavalcanti-Adam EA.   +6 more
europepmc   +1 more source

Simulation of cell movement through evolving environment: a fictitious domain approach [PDF]

, 2012
A numerical method for simulating the movement of unicellular organisms which respond to chemical signals is presented. Cells are modelled as objects of finite size while the extracellular space is described by reaction-diffusion partial differential ...
Burrage, K., Erban, R., Kay, D., Séguis, J. - C.   +3 more
core  

Properties of tug-of-war model for cargo transport by molecular motors

, 2009
Molecular motors are essential components for the biophysical functions of the cell. Our current quantitative understanding of how multiple motors move along a single track is not complete; even though models and theories for single motor chemomechanics ...
J. Howard, Melanie J. I. Müller, Yunxin Zhang   +2 more
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A/C-deficient mice

Cell Death Discovery
Lamins A and C, encoded by the LMNA gene, are nuclear intermediate filaments that provide structural support to the nucleus and contribute to chromatin organization and transcriptional regulation.
Tyler J. Kirby, Hind C. Zahr, Ern Hwei Hannah Fong, Jan Lammerding   +3 more
doaj   +1 more source

Palmitoylation Is Indispensable for Remorin to Restrict Tobacco Mosaic Virus Cell-to-Cell Movement in Nicotiana benthamiana. [PDF]

Viruses, 2022
Ma T, Fu S, Wang K, Wang Y, Wu J, Zhou X.   +5 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Mitochondrial Permeability Transition, Cell Death and Neurodegeneration

Cells
Neurodegenerative diseases are chronic conditions occurring when neurons die in specific brain regions that lead to loss of movement or cognitive functions.
Artyom Y. Baev, Andrey Y. Vinokurov, Elena V. Potapova, Andrey V. Dunaev, Plamena R. Angelova, Andrey Y. Abramov   +5 more
doaj   +1 more source

EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation. [PDF]

Cell Mol Life Sci, 2022
Fu C, Wang J, Pallikkuth S, Ding Y, Chen J, Wren JD, Yang Y, Wong KK, Kameyama H, Jayaraman M, Munshi A, Tanaka T, Lidke KA, Zhang XA.   +13 more
europepmc   +1 more source