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Protein Synthesis in the Cell Nucleus
Nature, 1955THERE is considerable evidence that the cytoplasm of the cell contains structures capable of carrying out protein synthesis1, and it has been shown in one case2 that formation of protein may be little affected by removal of the nucleus. These findings seem to exclude the appealing hypothesis that the nucleus is the source of the cell's proteins.
David M. Prescott, Daniel Mazia
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Cell Biology of the Plant Nucleus
Annual Review of Plant Biology, 2017The eukaryotic nucleus is enclosed by the nuclear envelope, which is perforated by the nuclear pores, the gateways of macromolecular exchange between the nucleoplasm and cytoplasm. The nucleoplasm is organized in a complex three-dimensional fashion that changes over time and in response to stimuli.
David E. Evans +3 more
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Functional architecture in the cell nucleus
Biochemical Journal, 2001The major functions of the cell nucleus, including transcription, pre-mRNA splicing and ribosome assembly, have been studied extensively by biochemical, genetic and molecular methods. An overwhelming amount of information about their molecular mechanisms is available. In stark contrast, very little is known about how these processes are integrated into
Tom Misteli, Miroslav Dundr
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Architecture of the Cell Nucleus
2010The nucleus is the largest of the cellular compartments, housing the chromosomes with the vast majority of the cellular genome, as well as multiple molecular machineries necessary for gene organisation and expression. During the past years contemporarily with the successful sequencing of the entire human genome, knowledge of nuclear architectures has ...
Jürgen Roth, Margit Pavelka
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Role of glutathione in cell nucleus
Free Radical Research, 2010Cells with high proliferation rate have high glutathione levels. This typical feature of cancer cells is viewed usually as a defence mechanism against ionizing radiation or chemotherapy. Efforts have been made in order to decrease cellular glutathione levels in tumours as a necessary pre-treatment for cancer therapy.
Jose Viña +4 more
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Dynamic organization of the cell nucleus
Current Opinion in Genetics & Development, 2007The dynamic organization of the cell nucleus into subcompartments with distinct biological activities represents an important regulatory layer for cell function. Recent studies provide new insights into the principles, by which nuclear organelles form.
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The reactivation of the red cell nucleus
Journal of Cell Science, 1967ABSTRACT When the nucleus of a mature hen erythrocyte is introduced into the cytoplasm of a HeLa cell it resumes the synthesis of RNA and DNA. This reactivation of the red cell nucleus in the heterokaryon is associated with a marked increase in its volume. There is a direct relationship between the volume of the nucleus and the amount of
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Ultrastructure of the cell nucleus
1963I have recently summarized our work on the ultrastructure of chromosomes [12, 13] and shall therefore only briefly review the main points with emphasis on recent findings.
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Signal Transduction to the Cell Nucleus
1992Publisher Summary This chapter presents the evidence pertaining to possible mechanisms of information transfer between the cytoplasm and the nucleus. Signal transduction from cytoplasm to nucleus is proposed to depend on the existence of equilibria in protein distributions across the nuclear envelope and on various mechanisms controlling the ...
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