Results 91 to 100 of about 73,798 (303)

Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]

, 2019
Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina, Duan, Xin, Pan, Hua, Pham, Christine T. N., Rai, Muhammad Farooq, Sandell, Linda J., Wickline, Samuel A., Yan, Huimin   +7 more
core   +3 more sources

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source

Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis

International Journal of Nanomedicine, 2014
Jin Sook Suh,1,* Jue Yeon Lee,2,* Yoon Jung Choi,1 Hyung Keun You,3 Seong-Doo Hong,4 Chong Pyoung Chung,2 Yoon Jeong Park1,2 1Dental Regenerative Biotechnology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 2Central ...
Suh JS, Lee JY, Choi YJ, You HK, Hong SD, Chung CP, Park YJ   +6 more
doaj  

Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro [PDF]

Exploration of Drug Science
Aim: The aim of this research was to generate new peptide molecules with cytotoxic activity against cervical cancer that can become effective in mitigating the impact of the disease and preventing its progression.
Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda   +7 more
doaj   +1 more source

Cell-Penetrating Peptides: Mechanisms and Applications

Current Pharmaceutical Design, 2005
A major obstacle in the development of new therapeutic agents is the low bioavailability of hydrophilic substances. Drugs that bind to intracellular targets must penetrate the lipid bilayer surrounding the cell in order to exert their effect. A relatively new research area that addresses this problem by introducing novel transport peptides that ...
El-Andaloussi, S, Holm, T, Langel, U
openaire   +2 more sources

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapy. [PDF]

PLoS ONE, 2013
PURPOSE: PP2A is a serine/threonine phosphatase critical to physiological processes, including apoptosis. Cell penetrating peptides are molecules that can translocate into cells without causing membrane damage.
Issam Arrouss, Fariba Nemati, Fernando Roncal, Marie Wislez, Karim Dorgham, David Vallerand, Nathalie Rabbe, Narjesse Karboul, Françoise Carlotti, Jeronimo Bravo, Dominique Mazier, Didier Decaudin, Angelita Rebollo   +12 more
doaj   +1 more source

Mitoparans: mitochondriotoxic cell penetrating peptides and novel inducers of apoptosis. [PDF]

, 2007
Acknowledgments The authors would like to thank Keith Holding at the University of Wolverhampton for his outstanding technical support. This work was supported in part by Samantha Dickson Brain Tumour Trust.Introduction: The amphipathic helical peptide ...
Belzacq-Casagrande, Anne-Sophie, Brenner, Catherine, Howl, John D., Jones, Sarah, Martel, Cecile   +4 more
core   +1 more source

CPPpred: prediction of cell penetrating peptides [PDF]

Bioinformatics, 2013
Abstract Summary: Cell penetrating peptides (CPPs) are attracting much attention as a means of overcoming the inherently poor cellular uptake of various bioactive molecules. Here, we introduce CPPpred, a web server for the prediction of CPPs using a N-to-1 neural network.
Thérèse A. Holton, Gianluca Pollastri, Denis C. Shields, Catherine Mooney   +3 more
openaire   +4 more sources

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, EarlyView.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source