Results 161 to 170 of about 5,360,136 (290)

Understanding cell-penetrating peptide mechanisms using computational electrophysiology simulations. [PDF]

Protein Sci
Catalina-Hernandez E, Aguilella-Arzo M, Lopez-Martin M, Peralvarez-Marin A.   +3 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Translational Assessment of a Cell-Penetrating Peptide Topical Formulation for Repairing Barrier Dysfunction in Human Skin. [PDF]

Int J Mol Sci
Lee YI, Min A, Kim W, Jung J, Choi H, Hwang JK, Nguyen NH, Jung I, Roh H.   +8 more
europepmc   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Utilization of cell-penetrating peptide adaptors to enhance delivery of variably charged protein cargos. [PDF]

PLoS One
Morris DP, Turner NI, Croffie JJ, McMurry JL.   +3 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Chemical Synthesis of Mirror-Image Proteins Reveals Chirality-Dependent Cellular Uptake Mediated by a Cell-Penetrating Peptide. [PDF]

J Am Chem Soc
Nassar E, Donthoju A, Hasan M, Brik A.
europepmc   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Cell-Penetrating Peptide-Mediated Modulation of Endoplasmic Reticulum Stress: A Bioengineered and Translational Approach. [PDF]

ACS Pharmacol Transl Sci
Paliwal T, Joshi R, Paliwal S, Chakraborty D, Sharma S.   +4 more
europepmc   +1 more source

Novel BUF2-magnetite nanobioconjugates with cell-penetrating abilities

, 2018
Monica Cuellar,1 Javier Cifuentes,1 Jessica Perez,1 Alejandra Suarez-Arnedo,1 Julian A Serna,1 Helena Groot,2 Carolina Muñoz-Camargo,1 Juan C Cruz1 1Department of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombia; 2Human ...
Suarez-Arnedo A, Cuellar M, Groot H, Muñoz-Camargo C, Cruz JC, Cifuentes J, Perez J, Serna JA   +7 more
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