Results 31 to 40 of about 73,798 (303)
Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Pharmaceuticals, 2010 The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo +3 more
doaj +1 more source
Uptake of cell‐penetrating peptides in yeasts [PDF]
FEBS Letters, 2005 The uptake of different cell‐penetrating peptides (CPPs) in two yeast species, Saccharomyces cerevisiae and Candida albicans, was studied using fluorescence HPLC‐analyses of cell content. Comparison of the ability of penetratin, pVEC and (KFF)3K to traverse the yeast cell envelope shows that the cellular uptake of the peptides varies widely.
Holm, Tina +4 more
openaire +2 more sources
Cell-penetrating Peptides [PDF]
Journal of Biological Chemistry, 2003 The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
Jean Philippe Richard +7 more
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A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice
Journal of Pharmacological Sciences, 2010 Nerve growth factor (NGF) and its high-affinity receptor, TrkA, are one of the targets in the production of new drugs for the treatment of neuropathic pain.
Wei-Ying Ma +7 more
doaj +1 more source
Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis
JCI Insight, 2021 To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration and/
Maryam Aftabizadeh +11 more
doaj +1 more source
Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]
, 2016 Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James +11 more
core +2 more sources
Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
Pharmaceuticals, 2012 Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells
Ülo Langel +2 more
doaj +1 more source
Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]
British Journal of Pharmacology, 2005 Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W. +6 more
openaire +2 more sources
Materials & Design, 2023 Effectively suppressing the hyperactivated inflammatory response is a critical strategy for treating inflammatory diseases, such as spinal cord injury (SCI) and rheumatoid arthritis (RA).
Zhuo Li +9 more
doaj +1 more source
Non-metabolic membrane tubulation and permeability induced by bioactive peptides. [PDF]
PLoS ONE, 2007 BACKGROUND:Basic cell-penetrating peptides are potential vectors for therapeutic molecules and display antimicrobial activity. The peptide-membrane contact is the first step of the sequential processes leading to peptide internalization and cell activity.
Antonin Lamazière +5 more
doaj +1 more source