Results 101 to 110 of about 809,436 (268)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Cross-talk-dependent cortical patterning of Rho GTPases during cell repair. [PDF]

Mol Biol Cell, 2021
Moe A, Holmes W, Golding AE, Zola J, Swider ZT, Edelstein-Keshet L, Bement W.   +6 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Cell adhesion and repair [PDF]

Journal of Investigative Dermatology, 2015
openaire   +2 more sources

Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis. [PDF]

Nat Aging, 2021
Childs BG, Zhang C, Shuja F, Sturmlechner I, Trewartha S, Fierro Velasco R, Baker D, Li H, van Deursen JM.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CX3CL1 release during immunogenic apoptosis is associated with enhanced anti-tumour immunity

Frontiers in Immunology
IntroductionImmunogenic cell death (ICD) has emerged as a novel option for cancer immunotherapy. The key determinants of ICD encompass antigenicity (the presence of antigens) and adjuvanticity, which involves the release of damage-associated molecular ...
Faye Naessens, Faye Naessens, Robin Demuynck, Robin Demuynck, Olga Vershinina, Iuliia Efimova, Iuliia Efimova, Mariia Saviuk, Mariia Saviuk, Greet De Smet, Tatiana A. Mishchenko, Maria V. Vedunova, Olga Krysko, Elena Catanzaro, Elena Catanzaro, Dmitri V. Krysko, Dmitri V. Krysko   +16 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy

Nature Communications
The type of cell death has proven to play a crucial role in cancer immunotherapy efficacy. Immunogenic cell death (ICD) enhances tumor adjuvanticity and antigenicity by releasing danger signals and altering the immune peptidome.
Mariia Saviuk, Victoria D. Turubanova, Sara De Brée, Sandra Van Lint, Teresa Mendes Maia, Simon Devos, Iuliia Efimova, Julie Braet, Lore Van Oudenhove, Gitta Boons, Faye Naessens, Robin Demuynck, Ellen Saeys, Christian Vanhove, Lukas Bunse, Peter M. van Endert, Robrecht Raedt, Maria V. Vedunova, Olga Krysko, Roosmarijn E. Vandenbroucke, Karim Vermaelen, Tatiana A. Mishchenko, Elena Catanzaro, Dmitri V. Krysko   +23 more
doaj   +1 more source