Results 71 to 80 of about 13,519,306 (307)
Cell Death & Differentiation, 2007 Peer ...
Sánchez, Ana, García-Sancho, Javier
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A novel TGFβ1–Hs3st2–tau axis regulates tau pathology and synaptic integrity
Frontiers in NeuroscienceIntroductionTauopathies are a group of neurodegenerative diseases characterized by the pathological accumulation of tau protein. The hippocampus, a brain region crucial for learning and memory, is particularly susceptible to tau-induced damage.
Rafael Castillo-Negrete +13 more
doaj +1 more source
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Nature reviews. Molecular cell biology, 2017 DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous
Howard H. Y. Chang +3 more
semanticscholar +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Comparison of Olfactory Bulbar and Mucosal Cultures in a Rat Rhizotomy Model
Cell Transplantation, 2014 In an ongoing clinical trial, a spinal injured patient who received a transplant of autologous cells cultured from the olfactory bulb is showing greater functional benefit than three previous patients with transplants of mucosal origin.
Ahmed Ibrahim +5 more
doaj +1 more source
“Self-repairing” nanoshell for cell protection
Chemical Science, 2015 Self-repairing biohybrid nanoshells provide living cells with high activity and extended viability in harsh micro-environments.
Jiang, Nan +12 more
openaire +4 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Journal of InflammationMinimizing unintended granulocyte activation while measuring functional responsiveness is essential, as the use of external probes, antibodies, or fluorescent dyes can potentially alter cellular responsiveness.
Anuruddika J. Fernando +8 more
doaj +1 more source
eLife, 2020 Previously we showed that YAP/TAZ promote not only proliferation but also differentiation of immature Schwann cells (SCs), thereby forming and maintaining the myelin sheath around peripheral axons (Grove et al., 2017).
Matthew Grove +3 more
doaj +1 more source