Results 231 to 240 of about 450,004 (307)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Bioenergetic and immunological characterization of cryopreserved peripheral blood mononuclear cells (PBMCs) isolated from blood and buffy coat. [PDF]

Front Mol Biosci
Dieter F, Grube J, Quentin A, Eckert GP.
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Extracellular Succinate Modulates Neuroimmune Responses in a Murine Microglial Cell Line. [PDF]

Biomolecules
Yudin SCY, Day K, Scott EY, Patel MN, Islam H, Klegeris A.   +5 more
europepmc   +1 more source

Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression. [PDF]

Cancer Res
Dubisova M, Bohacova K, Nahacka Z, Kraus D, Novak J, Dvorakova S, Brisudova P, Danesova N, Selvi S, Hrysiuk M, Endaya BB, Botsios P, Le DT, Novotna M, Vodenkova S, Truksa J, Chalupsky K, Klima K, Prochazka J, Sedlacek R, Mengarelli F, Orlando P, Tiano L, Boukalova S, Berridge MV, Zobalova R, Neuzil J.   +26 more
europepmc   +1 more source

Smarca4 maintains mitochondrial homeostasis and energy metabolism during cardiac development. [PDF]

Cell Mol Life Sci
Park DD, Kim S, Boos A, Andrasch Y, Krieg L, Rottbauer W, Just S.   +6 more
europepmc   +1 more source

Characterization of a <i>UQCRC1</i> variant in a patient with progressive weakness, pain and sleep issues reveals a functional mitochondrial defect restored by mitochondrial transplantation. [PDF]

Mol Genet Metab Rep
Piroli GG, Myers R, Holloway L, Hayek A, Linebaugh E, Jones JR, Skinner C, Skinner SA, Frizzell N, Steet R.   +9 more
europepmc   +1 more source

<i>APOE4</i> drives widespread changes to the hepatic proteome and alters metabolic function. [PDF]

iScience
Lysaker CR, Johnson CN, Csikos V, Franczak E, Tetlow AL, Benson M, Thyfault JP, Geiger PC, Morris JK, Wilkins HM.   +9 more
europepmc   +1 more source