Results 121 to 130 of about 772,872 (263)

Label-free blood cell separation for space health monitoring using a portable blast cell biochip. [PDF]

NPJ Microgravity
Mugnano M, Cerbone V, Villone MM, Montella A, Scalia G, Capasso M, Iolascon A, Miccio L, Ferraro P, Mari S, Ferranti F, Maffettone PL.   +11 more
europepmc   +1 more source

Optimal Parameter Configuration of a Microfluidic Chip for High-Throughput, Label-Free Circulating Tumor Cell Separation and Enrichment Based on Inertial Focusing. [PDF]

Diagnostics (Basel), 2023
Sun X, Ma Y, Lu C, Cai Z, Han J, Wang Z, Yang G.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Cell wall hydrolysis promotes a second wave of transpeptidation to achieve cell separation following septation in Bacillus subtilis. [PDF]

Nat Commun
Patel V, Hsu YP, Debnath M, Kearns DB, VanNieuwenhze MS, Brun YV.   +5 more
europepmc   +1 more source

A moonlighting role for LysM peptidoglycan binding domains underpins Enterococcus faecalis daughter cell separation. [PDF]

Commun Biol, 2023
Salamaga B, Turner RD, Elsarmane F, Galley NF, Kulakauskas S, Mesnage S.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Evaluating novel and conventional cell-separation techniques for sexual assault investigations. [PDF]

J Forensic Sci
Schulte J, Egger S, Kron S, Scheurer E, Schulz I.   +4 more
europepmc   +1 more source

Blood Cell Separation Using Polypropylene-Based Microfluidic Devices Based on Deterministic Lateral Displacement. [PDF]

Micromachines (Basel), 2023
Matsuura K, Takata K.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Bionic Sensing Platform for Cell Separation: Simulation of a Dielectrophoretic Microfluidic Device That Leverages Dielectric Fingerprints. [PDF]

Biomimetics (Basel)
Hadjiaghaie Vafaie R, Poorreza E, Sheykhivand S, Danishvar S.   +3 more
europepmc   +1 more source