Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Evaluating novel and conventional cell-separation techniques for sexual assault investigations. [PDF]
J Forensic SciSchulte J +4 more
europepmc +1 more source
A moonlighting role for LysM peptidoglycan binding domains underpins Enterococcus faecalis daughter cell separation. [PDF]
Commun Biol, 2023 Salamaga B +5 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Bionic Sensing Platform for Cell Separation: Simulation of a Dielectrophoretic Microfluidic Device That Leverages Dielectric Fingerprints. [PDF]
Biomimetics (Basel)Hadjiaghaie Vafaie R +3 more
europepmc +1 more source
Blood Cell Separation Using Polypropylene-Based Microfluidic Devices Based on Deterministic Lateral Displacement. [PDF]
Micromachines (Basel), 2023 Matsuura K, Takata K.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli. [PDF]
PLoS GenetHernández-Rocamora VM +13 more
europepmc +1 more source
Protocol of living cell separation using the microfluidic dielectrophoresis integrated chip. [PDF]
STAR Protoc, 2022 Koba K +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source